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MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis.
Katsarou A, Trasanidis N, Ponnusamy K, Kostopoulos IV, Alvarez-Benayas J, Papaleonidopoulou F, Keren K, Sabbattini PMR, Feldhahn N, Papaioannou M, Hatjiharissi E, Sudbery IM, Chaidos A, Caputo VS, Karadimitris A. Katsarou A, et al. Among authors: chaidos a. Blood Adv. 2023 Nov 14;7(21):6395-6410. doi: 10.1182/bloodadvances.2023009772. Blood Adv. 2023. PMID: 37224458 Free PMC article.
Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma.
Trasanidis N, Katsarou A, Ponnusamy K, Shen YA, Kostopoulos IV, Bergonia B, Keren K, Reema P, Xiao X, Szydlo RM, Sabbattini PMR, Roberts IAG, Auner HW, Naresh KN, Chaidos A, Wang TL, Magnani L, Caputo VS, Karadimitris A. Trasanidis N, et al. Among authors: chaidos a. Blood. 2022 Mar 31;139(13):1939-1953. doi: 10.1182/blood.2021014391. Blood. 2022. PMID: 35015835 Free article.
Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma.
Chaidos A, Barnes CP, Cowan G, May PC, Melo V, Hatjiharissi E, Papaioannou M, Harrington H, Doolittle H, Terpos E, Dimopoulos M, Abdalla S, Yarranton H, Naresh K, Foroni L, Reid A, Rahemtulla A, Stumpf M, Roberts I, Karadimitris A. Chaidos A, et al. Blood. 2013 Jan 10;121(2):318-28. doi: 10.1182/blood-2012-06-436220. Epub 2012 Nov 20. Blood. 2013. PMID: 23169779 Free article.
The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.
Ponnusamy K, Tzioni MM, Begum M, Robinson ME, Caputo VS, Katsarou A, Trasanidis N, Xiao X, Kostopoulos IV, Iskander D, Roberts I, Trivedi P, Auner HW, Naresh K, Chaidos A, Karadimitris A. Ponnusamy K, et al. Among authors: chaidos a. Haematologica. 2022 Mar 1;107(3):721-732. doi: 10.3324/haematol.2020.274480. Haematologica. 2022. PMID: 33596642 Free PMC article.
Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma.
Alvarez-Benayas J, Trasanidis N, Katsarou A, Ponnusamy K, Chaidos A, May PC, Xiao X, Bua M, Atta M, Roberts IAG, Auner HW, Hatjiharissi E, Papaioannou M, Caputo VS, Sudbery IM, Karadimitris A. Alvarez-Benayas J, et al. Among authors: chaidos a. Nat Commun. 2021 Sep 14;12(1):5450. doi: 10.1038/s41467-021-25704-2. Nat Commun. 2021. PMID: 34521827 Free PMC article.
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, Tough DF, Smithers NN, Bassil AK, Chapman TD, Harker NR, Barbash O, Tummino P, Al-Mahdi N, Haynes AC, Cutler L, Le B, Rahemtulla A, Roberts I, Kleijnen M, Witherington JJ, Parr NJ, Prinjha RK, Karadimitris A. Chaidos A, et al. Blood. 2014 Jan 30;123(5):697-705. doi: 10.1182/blood-2013-01-478420. Epub 2013 Dec 13. Blood. 2014. PMID: 24335499 Free article.
Myeloma Propagating Cells, Drug Resistance and Relapse.
Karadimitris A, Chaidos A, Caputo V, Goudevenou K, Ponnusamy K, Xiao X. Karadimitris A, et al. Among authors: chaidos a. Stem Cells. 2015 Nov;33(11):3205-11. doi: 10.1002/stem.2199. Epub 2015 Sep 28. Stem Cells. 2015. PMID: 26302895 Free article. Review.
76 results