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Role of CAR and PXR in xenobiotic sensing and metabolism.
Wang YM, Ong SS, Chai SC, Chen T. Wang YM, et al. Among authors: chai sc. Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):803-17. doi: 10.1517/17425255.2012.685237. Epub 2012 May 3. Expert Opin Drug Metab Toxicol. 2012. PMID: 22554043 Free PMC article. Review.
Pregnane X receptor and drug-induced liver injury.
Wang YM, Chai SC, Brewer CT, Chen T. Wang YM, et al. Among authors: chai sc. Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1521-32. doi: 10.1517/17425255.2014.963555. Epub 2014 Sep 25. Expert Opin Drug Metab Toxicol. 2014. PMID: 25252616 Free PMC article. Review.
Small-molecule modulators of the constitutive androstane receptor.
Cherian MT, Chai SC, Chen T. Cherian MT, et al. Among authors: chai sc. Expert Opin Drug Metab Toxicol. 2015 Jul;11(7):1099-114. doi: 10.1517/17425255.2015.1043887. Epub 2015 May 15. Expert Opin Drug Metab Toxicol. 2015. PMID: 25979168 Free PMC article. Review.
Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.
Wang YM, Chai SC, Lin W, Chai X, Elias A, Wu J, Ong SS, Pondugula SR, Beard JA, Schuetz EG, Zeng S, Xie W, Chen T. Wang YM, et al. Among authors: chai x, chai sc. Biochem Pharmacol. 2015 Aug 15;96(4):357-68. doi: 10.1016/j.bcp.2015.06.018. Epub 2015 Jun 25. Biochem Pharmacol. 2015. PMID: 26119819 Free PMC article.
135 results