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Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models.
Alsharif I, Boukhzar L, Lefranc B, Godefroy D, Aury-Landas J, Rego JD, Rego JD, Naudet F, Arabo A, Chagraoui A, Maltête D, Benazzouz A, Baugé C, Leprince J, Elkahloun AG, Eiden LE, Anouar Y. Alsharif I, et al. Among authors: chagraoui a. Redox Biol. 2021 Apr;40:101839. doi: 10.1016/j.redox.2020.101839. Epub 2020 Dec 28. Redox Biol. 2021. PMID: 33486153 Free PMC article.
The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes.
Tanguy Y, Falluel-Morel A, Arthaud S, Boukhzar L, Manecka DL, Chagraoui A, Prevost G, Elias S, Dorval-Coiffec I, Lesage J, Vieau D, Lihrmann I, Jégou B, Anouar Y. Tanguy Y, et al. Among authors: chagraoui a. Endocrinology. 2011 Nov;152(11):4322-35. doi: 10.1210/en.2011-1246. Epub 2011 Sep 6. Endocrinology. 2011. PMID: 21896670 Free article.
Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.
Boukhzar L, Hamieh A, Cartier D, Tanguy Y, Alsharif I, Castex M, Arabo A, El Hajji S, Bonnet JJ, Errami M, Falluel-Morel A, Chagraoui A, Lihrmann I, Anouar Y. Boukhzar L, et al. Among authors: chagraoui a. Antioxid Redox Signal. 2016 Apr 10;24(11):557-74. doi: 10.1089/ars.2015.6478. Epub 2016 Mar 16. Antioxid Redox Signal. 2016. PMID: 26866473 Free PMC article.
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: chagraoui a. Eur J Pharmacol. 2024 Mar 5;966:176329. doi: 10.1016/j.ejphar.2024.176329. Epub 2024 Jan 20. Eur J Pharmacol. 2024. PMID: 38253116
57 results