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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Among authors: chaggar hk. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
Klotho inhibits neuronal senescence in human brain organoids.
Shaker MR, Aguado J, Chaggar HK, Wolvetang EJ. Shaker MR, et al. Among authors: chaggar hk. NPJ Aging Mech Dis. 2021 Aug 2;7(1):18. doi: 10.1038/s41514-021-00070-x. NPJ Aging Mech Dis. 2021. PMID: 34341344 Free PMC article.