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Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing-Proof of concept for virus filtration.
Biotechnol Bioeng. 2022 Aug;119(8):2134-2141. doi: 10.1002/bit.28119. Epub 2022 May 5.
Biotechnol Bioeng. 2022.
PMID: 35470427
Use of a noninfectious surrogate to predict minute virus of mice removal during nanofiltration.
Cetlin D, Pallansch M, Fulton C, Vyas E, Shah A, Sohka T, Dhar A, Pallansch L, Strauss D.
Cetlin D, et al.
Biotechnol Prog. 2018 Sep;34(5):1213-1220. doi: 10.1002/btpr.2694. Epub 2018 Sep 8.
Biotechnol Prog. 2018.
PMID: 30194917
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Using a noninfectious MVM surrogate for assessing viral clearance during downstream process development.
Orchard JD, Cetlin D, Pallansch M, Barlow R, Borman J, Dhar A, Pallansch L, Dickson M.
Orchard JD, et al. Among authors: cetlin d.
Biotechnol Prog. 2020 Jan;36(1):e2921. doi: 10.1002/btpr.2921. Epub 2019 Oct 14.
Biotechnol Prog. 2020.
PMID: 31587529
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High throughput chromatography and analytics can inform viral clearance capabilities during downstream process development for biologics.
Gulla KC, Schneiderman ZJ, O'Connell SE, Arias GF, Cibelli NL, Cetlin D, Gowetski DB.
Gulla KC, et al. Among authors: cetlin d.
Biotechnol J. 2021 Sep;16(9):e2000641. doi: 10.1002/biot.202000641. Epub 2021 Jul 29.
Biotechnol J. 2021.
PMID: 34174016
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Characterization of Non-Infectious Virus-Like Particle Surrogates for Viral Clearance Applications.
Johnson S, Brorson KA, Frey DD, Dhar AK, Cetlin DA.
Johnson S, et al. Among authors: cetlin da.
Appl Biochem Biotechnol. 2017 Sep;183(1):318-331. doi: 10.1007/s12010-017-2447-y. Epub 2017 Mar 9.
Appl Biochem Biotechnol. 2017.
PMID: 28281181
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Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions.
Barnard JG, Kahn D, Cetlin D, Randolph TW, Carpenter JF.
Barnard JG, et al. Among authors: cetlin d.
J Pharm Sci. 2014 Mar;103(3):890-9. doi: 10.1002/jps.23881. Epub 2014 Jan 24.
J Pharm Sci. 2014.
PMID: 24549732
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