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Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GF, Hoogenraad CC, Capitani G, Kammerer RA. Benoit RM, et al. Among authors: ceska t. Nature. 2014 Jan 2;505(7481):108-11. doi: 10.1038/nature12732. Epub 2013 Nov 17. Nature. 2014. PMID: 24240280
Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.
Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP. Jnoff E, et al. Among authors: ceska t. ChemMedChem. 2014 Apr;9(4):699-705. doi: 10.1002/cmdc.201300525. Epub 2014 Feb 6. ChemMedChem. 2014. PMID: 24504667
Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
O'Connell J, Porter J, Kroeplien B, Norman T, Rapecki S, Davis R, McMillan D, Arakaki T, Burgin A, Fox Iii D, Ceska T, Lecomte F, Maloney A, Vugler A, Carrington B, Cossins BP, Bourne T, Lawson A. O'Connell J, et al. Among authors: ceska t. Nat Commun. 2019 Dec 19;10(1):5795. doi: 10.1038/s41467-019-13616-1. Nat Commun. 2019. PMID: 31857588 Free PMC article.
Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Hall A, Abendroth J, Bolejack MJ, Ceska T, Dell'Aiera S, Ellis V, Fox D 3rd, François C, Muruthi MM, Prével C, Poullennec K, Romanov S, Valade A, Vanbellinghen A, Yano J, Geraerts M. Hall A, et al. Among authors: ceska t. ACS Med Chem Lett. 2022 Jun 25;13(7):1099-1108. doi: 10.1021/acsmedchemlett.2c00134. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859861 Free PMC article.
Direct observation of DNA threading in flap endonuclease complexes.
AlMalki FA, Flemming CS, Zhang J, Feng M, Sedelnikova SE, Ceska T, Rafferty JB, Sayers JR, Artymiuk PJ. AlMalki FA, et al. Among authors: ceska t. Nat Struct Mol Biol. 2016 Jul;23(7):640-6. doi: 10.1038/nsmb.3241. Epub 2016 Jun 6. Nat Struct Mol Biol. 2016. PMID: 27273516 Free PMC article.
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Mitropoulou AN, Ceska T, Heads JT, Beavil AJ, Henry AJ, McDonnell JM, Sutton BJ, Davies AM. Mitropoulou AN, et al. Among authors: ceska t. Acta Crystallogr F Struct Biol Commun. 2020 Mar 1;76(Pt 3):116-129. doi: 10.1107/S2053230X20001466. Epub 2020 Mar 2. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32133997 Free PMC article.
48 results