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P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.
Lin KH, Rutter JC, Xie A, Killarney ST, Vaganay C, Benaksas C, Ling F, Sodaro G, Meslin PA, Bassil CF, Fenouille N, Hoj J, Washart R, Ang HX, Cerda-Smith C, Chaintreuil P, Jacquel A, Auberger P, Forget A, Itzykson R, Lu M, Lin J, Pierobon M, Sheng Z, Li X, Chilkoti A, Owzar K, Rizzieri DA, Pardee TS, Benajiba L, Petricoin E, Puissant A, Wood KC. Lin KH, et al. Among authors: cerda smith c. Nat Cancer. 2022 Jul;3(7):837-851. doi: 10.1038/s43018-022-00394-x. Epub 2022 Jun 6. Nat Cancer. 2022. PMID: 35668193 Free PMC article.
ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.
Mayro B, Hoj JP, Cerda-Smith CG, Hutchinson HM, Caminear MW, Thrash HL, Winter PS, Wardell SE, McDonnell DP, Wu C, Wood KC, Pendergast AM. Mayro B, et al. Among authors: cerda smith cg. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2210418120. doi: 10.1073/pnas.2210418120. Epub 2023 Apr 11. Proc Natl Acad Sci U S A. 2023. PMID: 37040401 Free PMC article.
Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.
Ang HX, Sutiman N, Deng XL, Liu A, Cerda-Smith CG, Hutchinson HM, Kim H, Bartelt LC, Chen Q, Barrera A, Lin J, Sheng Z, McDowell IC, Reddy TE, Nicchitta CV, Wood KC. Ang HX, et al. Among authors: cerda smith cg. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2221448120. doi: 10.1073/pnas.2221448120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695916 Free PMC article.
Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1.
Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DW. Holmes S, et al. Among authors: cerda smith c. ACS Med Chem Lett. 2024 Jan 2;15(1):107-115. doi: 10.1021/acsmedchemlett.3c00464. eCollection 2024 Jan 11. ACS Med Chem Lett. 2024. PMID: 38229743 Free PMC article.
Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers.
Wood K, Nussbaum D, Martz C, Waters A, Barrera A, Rutter J, Cerda-Smith C, Stewart A, Wu C, Cakir M, Levandowski C, Kantrowitz D, McCall S, Pierobon M, Petricoin E 3rd, Smith J, Der C, Taatjes D. Wood K, et al. Among authors: cerda smith c. Res Sq [Preprint]. 2023 Nov 2:rs.3.rs-3511242. doi: 10.21203/rs.3.rs-3511242/v1. Res Sq. 2023. PMID: 37961649 Free PMC article. Preprint.
Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization.
Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casaní-Galdón S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC. Cerda-Smith CG, et al. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.558459. doi: 10.1101/2023.09.20.558459. bioRxiv. 2023. PMID: 37786671 Free PMC article. Preprint.
MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1.
Bassil CF, Anderson GR, Mayro B, Askin KN, Winter PS, Gruber S, Hall TM, Hoj JP, Cerda-Smith C, Hutchinson HM, Killarney ST, Singleton KR, Qin L, Jubien-Girard K, Favreau C, Martin AR, Robert G, Benhida R, Auberger P, Pendergast AM, Lonard DM, Puissant A, Wood KC. Bassil CF, et al. Among authors: cerda smith c. bioRxiv [Preprint]. 2023 Jan 19:2023.01.17.524094. doi: 10.1101/2023.01.17.524094. bioRxiv. 2023. PMID: 36711936 Free PMC article. Preprint.