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Microglia in Alzheimer's Disease in the Context of Tau Pathology.
Perea JR, Bolós M, Avila J. Perea JR, et al. Biomolecules. 2020 Oct 14;10(10):1439. doi: 10.3390/biom10101439. Biomolecules. 2020. PMID: 33066368 Free PMC article. Review.
Given that most clinical trials following this strategy have failed, current endeavors focus on deciphering the molecular mechanisms that trigger the tau-induced inflammatory response of microglia. ...
Given that most clinical trials following this strategy have failed, current endeavors focus on deciphering the molecular mechanisms …
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.
Bertacchi M, Gruart A, Kaimakis P, Allet C, Serra L, Giacobini P, Delgado-García JM, Bovolenta P, Studer M. Bertacchi M, et al. EMBO Mol Med. 2019 Aug;11(8):e10291. doi: 10.15252/emmm.201910291. Epub 2019 Jul 18. EMBO Mol Med. 2019. PMID: 31318166 Free PMC article.
Importantly, some of these clinical features, such the optic nerve hypomyelination, could be rescued by chemical drug treatment in early postnatal life. Overall, our data shed new insights into the cellular mechanisms of optic nerve atrophy in BBSOA patients and open a pro …
Importantly, some of these clinical features, such the optic nerve hypomyelination, could be rescued by chemical drug treatment in ea …
The archaeology of coding RNA.
Ariza-Mateos A, Briones C, Perales C, Domingo E, Gómez J. Ariza-Mateos A, et al. Ann N Y Acad Sci. 2019 Jul;1447(1):119-134. doi: 10.1111/nyas.14173. Epub 2019 Jun 25. Ann N Y Acad Sci. 2019. PMID: 31237363 Review.