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Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin.
Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, Covacci A. Xiang Z, et al. Among authors: censini s. Infect Immun. 1995 Jan;63(1):94-8. doi: 10.1128/iai.63.1.94-98.1995. Infect Immun. 1995. PMID: 7806390 Free PMC article.
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Marchetti M, Rossi M, Giannelli V, Giuliani MM, Pizza M, Censini S, Covacci A, Massari P, Pagliaccia C, Manetti R, Telford JL, Douce G, Dougan G, Rappuoli R, Ghiara P. Marchetti M, et al. Among authors: censini s. Vaccine. 1998 Jan;16(1):33-7. doi: 10.1016/s0264-410x(97)00153-9. Vaccine. 1998. PMID: 9607006
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