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Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors.
Trocóniz IF, Cendrós JM, Soto E, Pruñonosa J, Perez-Mayoral A, Peraire C, Principe P, Delavault P, Cvitkovic F, Lesimple T, Obach R. Trocóniz IF, et al. Among authors: cendros jm. Cancer Chemother Pharmacol. 2012 Aug;70(2):239-50. doi: 10.1007/s00280-012-1906-y. Epub 2012 Jun 15. Cancer Chemother Pharmacol. 2012. PMID: 22699813 Clinical Trial.
Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumours.
Trocòniz IF, Garrido MJ, Segura C, Cendrós JM, Principe P, Peraire C, Obach R. Trocòniz IF, et al. Among authors: cendros jm. Cancer Chemother Pharmacol. 2006 Jun;57(6):727-35. doi: 10.1007/s00280-005-0112-6. Epub 2005 Oct 28. Cancer Chemother Pharmacol. 2006. PMID: 16261364 Clinical Trial.
Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.
Soto E, Keizer RJ, Trocóniz IF, Huitema AD, Beijnen JH, Schellens JH, Wanders J, Cendrós JM, Obach R, Peraire C, Friberg LE, Karlsson MO. Soto E, et al. Among authors: cendros jm. Invest New Drugs. 2011 Oct;29(5):984-95. doi: 10.1007/s10637-010-9437-z. Epub 2010 May 7. Invest New Drugs. 2011. PMID: 20449627 Free PMC article. Clinical Trial.
14 results