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AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation.
Faienza F, Polverino F, Rajendraprasad G, Milletti G, Hu Z, Colella B, Gargano D, Strappazzon F, Rizza S, Vistesen MV, Luo Y, Antonioli M, Cianfanelli V, Ferraina C, Fimia GM, Filomeni G, De Zio D, Dengjel J, Barisic M, Guarguaglini G, Di Bartolomeo S, Cecconi F. Faienza F, et al. Among authors: cecconi f. Cell Mol Life Sci. 2023 Aug 16;80(9):251. doi: 10.1007/s00018-023-04878-6. Cell Mol Life Sci. 2023. PMID: 37584777 Free PMC article.
Ambra1 at a glance.
Cianfanelli V, De Zio D, Di Bartolomeo S, Nazio F, Strappazzon F, Cecconi F. Cianfanelli V, et al. Among authors: cecconi f. J Cell Sci. 2015 Jun 1;128(11):2003-8. doi: 10.1242/jcs.168153. J Cell Sci. 2015. PMID: 26034061 Review.
Ambra1 regulates autophagy and development of the nervous system.
Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F. Fimia GM, et al. Among authors: cecconi f. Nature. 2007 Jun 28;447(7148):1121-5. doi: 10.1038/nature05925. Epub 2007 Jun 24. Nature. 2007. PMID: 17589504
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.
Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M, Pagliarini V, Matteoni S, Fuoco C, Giunta L, D'Amelio M, Nardacci R, Romagnoli A, Piacentini M, Cecconi F, Fimia GM. Di Bartolomeo S, et al. Among authors: cecconi f. J Cell Biol. 2010 Oct 4;191(1):155-68. doi: 10.1083/jcb.201002100. J Cell Biol. 2010. PMID: 20921139 Free PMC article.
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, Levine B, Cecconi F. Strappazzon F, et al. Among authors: cecconi f. EMBO J. 2011 Apr 6;30(7):1195-208. doi: 10.1038/emboj.2011.49. Epub 2011 Feb 25. EMBO J. 2011. PMID: 21358617 Free PMC article.
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.
Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, Cecconi F. Strappazzon F, et al. Among authors: cecconi f. Cell Death Differ. 2015 Mar;22(3):419-32. doi: 10.1038/cdd.2014.139. Epub 2014 Sep 12. Cell Death Differ. 2015. PMID: 25215947 Free PMC article.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
Cianfanelli V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, Skobo T, Bordi M, Rohde M, Dalla Valle L, Helmer-Citterich M, Gretzmeier C, Dengjel J, Fimia GM, Piacentini M, Di Bartolomeo S, Velasco G, Cecconi F. Cianfanelli V, et al. Among authors: cecconi f. Nat Cell Biol. 2015 Jan;17(1):20-30. doi: 10.1038/ncb3072. Epub 2014 Dec 1. Nat Cell Biol. 2015. PMID: 25438055 Free PMC article.
312 results