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Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Larose H, Prokoph N, Matthews JD, Schlederer M, Högler S, Alsulami AF, Ducray SP, Nuglozeh E, Fazaludeen FMS, Elmouna A, Ceccon M, Mologni L, Gambacorti-Passerini C, Hoefler G, Lobello C, Pospisilova S, Janikova A, Woessmann W, Damm-Welk C, Zimmermann M, Federova A, Malone A, Smith O, Wasik M, Inghirami G, Lamant L, Blundell TL, Klapper W, Merkel O, Burke AGA, Mian S, Ashankyty I, Kenner L, Turner SD. Larose H, et al. Among authors: ceccon m. Haematologica. 2021 Jun 1;106(6):1693-1704. doi: 10.3324/haematol.2019.238766. Haematologica. 2021. PMID: 32327503 Free PMC article.
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Ceccon M, Merlo MEB, Mologni L, Poggio T, Varesio LM, Menotti M, Bombelli S, Rigolio R, Manazza AD, Di Giacomo F, Ambrogio C, Giudici G, Casati C, Mastini C, Compagno M, Turner SD, Gambacorti-Passerini C, Chiarle R, Voena C. Ceccon M, et al. Oncogene. 2016 Jul 21;35(29):3854-3865. doi: 10.1038/onc.2015.456. Epub 2015 Dec 14. Oncogene. 2016. PMID: 26657151 Free PMC article.
Identification of non-ATP-competitive α-carboline inhibitors of the anaplastic lymphoma kinase.
Mologni L, Orsato A, Zambon A, Tardy S, Bisson WH, Schneider C, Ceccon M, Viltadi M, D'Attoma J, Pannilunghi S, Vece V, Gueyrard D, Bertho J, Scapozza L, Goekjian P, Gambacorti-Passerini C. Mologni L, et al. Among authors: ceccon m. Eur J Med Chem. 2022 Aug 5;238:114488. doi: 10.1016/j.ejmech.2022.114488. Epub 2022 May 25. Eur J Med Chem. 2022. PMID: 35665691
86 results