Human airway trypsin-like protease exerts potent, antifibrotic action in pulmonary fibrosis.
Menou A, Flajolet P, Duitman J, Justet A, Moog S, Jaillet M, Tabèze L, Solhonne B, Garnier M, Mal H, Mordant P, Castier Y, Cazes A, Sallenave JM, Mailleux AA, Crestani B.
Menou A, et al. Among authors: cazes a.
FASEB J. 2018 Mar;32(3):1250-1264. doi: 10.1096/fj.201700583R. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29122847
In vitro, HAT prevented specific fibrosis-associated responses in primary human pulmonary fibroblasts and induced the expression of mediators associated with the prostaglandin E2 pathway. Altogether, our findings suggested that HAT could have a protective role in IPF and o …
In vitro, HAT prevented specific fibrosis-associated responses in primary human pulmonary fibroblasts and induced the expression of mediator …