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Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6).
Mardon K, Patel JZ, Savinainen JR, Stimson DHR, Oyagawa CRM, Grimsey NL, Migotto MA, Njiru GFM, Hamilton BR, Cowin G, Yli-Kauhaluoma J, Vanduffel W, Blakey I, Bhalla R, Cawthorne C, Celen S, Bormans G, Thurecht KJ, Ahamed M. Mardon K, et al. Among authors: cawthorne c. J Med Chem. 2023 Jan 12;66(1):538-552. doi: 10.1021/acs.jmedchem.2c01485. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36516997
Automated GMP compliant production of [18F]AlF-NOTA-octreotide.
Tshibangu T, Cawthorne C, Serdons K, Pauwels E, Gsell W, Bormans G, Deroose CM, Cleeren F. Tshibangu T, et al. Among authors: cawthorne c. EJNMMI Radiopharm Chem. 2020 Jan 29;5(1):4. doi: 10.1186/s41181-019-0084-1. EJNMMI Radiopharm Chem. 2020. PMID: 31997090 Free PMC article.
Translation of HDAC6 PET Imaging Using [18F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates.
Celen S, Rokka J, Gilbert TM, Koole M, Vermeulen I, Serdons K, Schroeder FA, Wagner FF, Bleeser T, Hightower BG, Hu J, Rahal D, Beyzavi H, Vanduffel W, Van Laere K, Kranz JE, Hooker JM, Bormans G, Cawthorne CJ. Celen S, et al. ACS Chem Neurosci. 2020 Apr 1;11(7):1093-1101. doi: 10.1021/acschemneuro.0c00074. Epub 2020 Mar 19. ACS Chem Neurosci. 2020. PMID: 32159328 Free PMC article.
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain.
Koole M, Van Weehaeghe D, Serdons K, Herbots M, Cawthorne C, Celen S, Schroeder FA, Hooker JM, Bormans G, de Hoon J, Kranz JE, Van Laere K, Gilbert TM. Koole M, et al. Among authors: cawthorne c. Eur J Nucl Med Mol Imaging. 2021 Feb;48(2):596-611. doi: 10.1007/s00259-020-04891-y. Epub 2020 Jul 8. Eur J Nucl Med Mol Imaging. 2021. PMID: 32638097 Free PMC article.
72 results