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Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D. Franceschi C, et al. Among authors: cavallone l. Mech Ageing Dev. 2005 Feb;126(2):351-61. doi: 10.1016/j.mad.2004.08.028. Mech Ageing Dev. 2005. PMID: 15621218 Review.
The role of IL-1 gene cluster in longevity: a study in Italian population.
Cavallone L, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Giovagnetti S, Di Stasio G, Giampieri C, Mugianesi E, Stecconi R, Sciacca F, Grimaldi LM, De Benedictis G, Lio D, Caruso C, Franceschi C. Cavallone L, et al. Mech Ageing Dev. 2003 Apr;124(4):533-8. doi: 10.1016/s0047-6374(03)00033-2. Mech Ageing Dev. 2003. PMID: 12714264
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C. Olivieri F, et al. Among authors: cavallone l. Mech Ageing Dev. 2003 Apr;124(4):549-53. doi: 10.1016/s0047-6374(03)00035-6. Mech Ageing Dev. 2003. PMID: 12714266
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.
Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Stecconi R, Molendini C, Trapassi C, De Benedictis G, Kletsas D, Franceschi C. Carrieri G, et al. Among authors: cavallone l. Aging Cell. 2004 Dec;3(6):443-8. doi: 10.1111/j.1474-9728.2004.00129.x. Aging Cell. 2004. PMID: 15569360 Free article.
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C. Bonafè M, et al. Among authors: cavallone l. Eur J Hum Genet. 2002 May;10(5):292-6. doi: 10.1038/sj.ejhg.5200806. Eur J Hum Genet. 2002. PMID: 12082503
A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.
Giampieri C, Centurelli M, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Cavallone L, Giovagnetti S, Mugianesi E, Carrieri G, Lisa R, Cenerelli S, Testa R, Boemi M, Petropoulou C, Gonos ES, Franceschi C. Giampieri C, et al. Among authors: cavallone l. Gene. 2004 Mar 3;327(2):215-9. doi: 10.1016/j.gene.2003.11.003. Gene. 2004. PMID: 14980718
Aging, longevity, inflammation, and cancer.
Caruso C, Lio D, Cavallone L, Franceschi C. Caruso C, et al. Among authors: cavallone l. Ann N Y Acad Sci. 2004 Dec;1028:1-13. doi: 10.1196/annals.1322.001. Ann N Y Acad Sci. 2004. PMID: 15915584 Review.
The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients.
Antonicelli R, Olivieri F, Bonafè M, Cavallone L, Spazzafumo L, Marchegiani F, Cardelli M, Recanatini A, Testarmata P, Boemi M, Parati G, Franceschi C. Antonicelli R, et al. Among authors: cavallone l. Int J Cardiol. 2005 Sep 1;103(3):266-71. doi: 10.1016/j.ijcard.2004.08.064. Int J Cardiol. 2005. PMID: 16098388
Paraoxonase activity and genotype predispose to successful aging.
Marchegiani F, Marra M, Spazzafumo L, James RW, Boemi M, Olivieri F, Cardelli M, Cavallone L, Bonfigli AR, Franceschi C. Marchegiani F, et al. Among authors: cavallone l. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):541-6. doi: 10.1093/gerona/61.6.541. J Gerontol A Biol Sci Med Sci. 2006. PMID: 16799134
67 results