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Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism.
Puca AA, Carrizzo A, Spinelli C, Damato A, Ambrosio M, Villa F, Ferrario A, Maciag A, Fornai F, Lenzi P, Valenti V, di Nonno F, Accarino G, Madonna M, Forte M, Calì G, Baragetti A, Norata GD, Catapano AL, Cattaneo M, Izzo R, Trimarco V, Montella F, Versaci F, Auricchio A, Frati G, Sciarretta S, Madeddu P, Ciaglia E, Vecchione C. Puca AA, et al. Among authors: cattaneo m. Eur Heart J. 2020 Jul 7;41(26):2487-2497. doi: 10.1093/eurheartj/ehz459. Eur Heart J. 2020. PMID: 31289820 Free PMC article.
The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
Di Pardo A, Ciaglia E, Cattaneo M, Maciag A, Montella F, Lopardo V, Ferrario A, Villa F, Madonna M, Amico E, Carrizzo A, Damato A, Pepe G, Marracino F, Auricchio A, Vecchione C, Maglione V, Puca AA. Di Pardo A, et al. Among authors: cattaneo m. Cell Death Dis. 2020 Jul 18;11(7):546. doi: 10.1038/s41419-020-02754-w. Cell Death Dis. 2020. PMID: 32683420 Free PMC article.
Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline.
Ciaglia E, Lopardo V, Montella F, Carrizzo A, Di Pietro P, Malavolta M, Giacconi R, Orlando F, Cattaneo M, Madeddu P, Vecchione C, Puca AA. Ciaglia E, et al. Among authors: cattaneo m. Cell Death Dis. 2022 Jan 27;13(1):86. doi: 10.1038/s41419-022-04535-z. Cell Death Dis. 2022. PMID: 35087020 Free PMC article.
BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice.
Cattaneo M, Aleksova A, Malovini A, Avolio E, Thomas A, Alvino VV, Kilcooley M, Pieronne-Deperrois M, Ouvrard-Pascaud A, Maciag A, Spinetti G, Kussauer S, Lemcke H, Skorska A, Vasudevan P, Castiglione S, Raucci A, David R, Richard V, Beltrami AP, Madeddu P, Puca AA. Cattaneo M, et al. Cell Death Dis. 2023 Aug 15;14(8):523. doi: 10.1038/s41419-023-06011-8. Cell Death Dis. 2023. PMID: 37582912 Free PMC article.
935 results