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Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.
Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VL, Souza AS, Guimarães ALA, Bellio M, Marcondes de Souza J, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST. Figueiredo CP, et al. Among authors: castro ng. Nat Commun. 2019 Sep 5;10(1):3890. doi: 10.1038/s41467-019-11866-7. Nat Commun. 2019. PMID: 31488835 Free PMC article.
Astrocyte-induced synaptogenesis is mediated by transforming growth factor β signaling through modulation of D-serine levels in cerebral cortex neurons.
Diniz LP, Almeida JC, Tortelli V, Vargas Lopes C, Setti-Perdigão P, Stipursky J, Kahn SA, Romão LF, de Miranda J, Alves-Leon SV, de Souza JM, Castro NG, Panizzutti R, Gomes FC. Diniz LP, et al. Among authors: castro ng. J Biol Chem. 2012 Nov 30;287(49):41432-45. doi: 10.1074/jbc.M112.380824. Epub 2012 Oct 10. J Biol Chem. 2012. PMID: 23055518 Free PMC article.
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimarães MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C Jr. Dias KS, et al. Among authors: castro ng. Eur J Med Chem. 2017 Apr 21;130:440-457. doi: 10.1016/j.ejmech.2017.02.043. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28282613
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.
Acquarone M, de Melo TM, Meireles F, Brito-Moreira J, Oliveira G, Ferreira ST, Castro NG, Tovar-Moll F, Houzel JC, Rehen SK. Acquarone M, et al. Among authors: castro ng. Front Cell Neurosci. 2015 Apr 8;9:97. doi: 10.3389/fncel.2015.00097. eCollection 2015. Front Cell Neurosci. 2015. PMID: 25904842 Free PMC article.
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C Jr. Dias Viegas FP, et al. Among authors: castro ng. Eur J Med Chem. 2018 Mar 10;147:48-65. doi: 10.1016/j.ejmech.2018.01.066. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29421570
P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels.
Santos SACS, Persechini PM, Henriques-Santos BM, Bello-Santos VG, Castro NG, Costa de Sousa J, Genta FA, Santiago MF, Coutinho-Silva R, Savio LEB, Kurtenbach E. Santos SACS, et al. Among authors: castro ng. Front Immunol. 2022 Feb 9;13:752105. doi: 10.3389/fimmu.2022.752105. eCollection 2022. Front Immunol. 2022. PMID: 35222364 Free PMC article.
44 results