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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
Fred SM, Laukkanen L, Brunello CA, Vesa L, Göös H, Cardon I, Moliner R, Maritzen T, Varjosalo M, Casarotto PC, Castrén E. Fred SM, et al. Among authors: castren e. J Biol Chem. 2019 Nov 29;294(48):18150-18161. doi: 10.1074/jbc.RA119.008837. Epub 2019 Oct 20. J Biol Chem. 2019. PMID: 31631060 Free PMC article.
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.
Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, Chao MV, Männistö PT, Castrén E. Rantamäki T, et al. Among authors: castren e. Neuropsychopharmacology. 2007 Oct;32(10):2152-62. doi: 10.1038/sj.npp.1301345. Epub 2007 Feb 21. Neuropsychopharmacology. 2007. PMID: 17314919
Targeting TrkB neurotrophin receptor to treat depression.
Rantamäki T, Castrén E. Rantamäki T, et al. Among authors: castren e. Expert Opin Ther Targets. 2008 Jun;12(6):705-15. doi: 10.1517/14728222.12.6.705. Expert Opin Ther Targets. 2008. PMID: 18479217 Review.
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. Rantamäki T, et al. Among authors: castren e. PLoS One. 2013 Jul 3;8(7):e68722. doi: 10.1371/journal.pone.0068722. Print 2013. PLoS One. 2013. PMID: 23844236 Free PMC article.
247 results