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The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self.
Cavazzoni CB, Bozza VBT, Lucas TCV, Conde L, Maia B, Mesin L, Schiepers A, Ersching J, Neris RLS, Conde JN, Coelho DR, Lima TM, Alvim RGF, Castilho LR, de Paula Neto HA, Mohana-Borges R, Assunção-Miranda I, Nobrega A, Victora GD, Vale AM. Cavazzoni CB, et al. Among authors: castilho lr. J Exp Med. 2021 Sep 6;218(9):e20210580. doi: 10.1084/jem.20210580. Epub 2021 Jul 22. J Exp Med. 2021. PMID: 34292314 Free PMC article.
Rapid development of a DNA vaccine for Zika virus.
Dowd KA, Ko SY, Morabito KM, Yang ES, Pelc RS, DeMaso CR, Castilho LR, Abbink P, Boyd M, Nityanandam R, Gordon DN, Gallagher JR, Chen X, Todd JP, Tsybovsky Y, Harris A, Huang YS, Higgs S, Vanlandingham DL, Andersen H, Lewis MG, De La Barrera R, Eckels KH, Jarman RG, Nason MC, Barouch DH, Roederer M, Kong WP, Mascola JR, Pierson TC, Graham BS. Dowd KA, et al. Among authors: castilho lr. Science. 2016 Oct 14;354(6309):237-240. doi: 10.1126/science.aai9137. Epub 2016 Sep 22. Science. 2016. PMID: 27708058 Free PMC article.
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study.
Kurtz P, Righy C, Gadelha M, Bozza FA, Bozza PT, Gonçalves B, Bastos LSL, Vale AM, Higa LM, Castilho L, Monteiro FL, Charris N, Fialho F, Turon R, Guterres A, Lyra Miranda R, de Azeredo Lima CH, de Caro V, Prazeres MA, Ventura N, Gaspari C, Miranda F, Jose da Mata P, Pêcego M, Mateos S, Lopes ME, Castilho S, Oliveira Á, Boquimpani C, Rabello A, Lopes J, Neto OC, Ferreira ODC Jr, Tanuri A, Filho PN, Amorim L. Kurtz P, et al. Front Med (Lausanne). 2021 Jan 28;8:630982. doi: 10.3389/fmed.2021.630982. eCollection 2021. Front Med (Lausanne). 2021. PMID: 33585529 Free PMC article.
Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients.
Fahad AS, Timm MR, Madan B, Burgomaster KE, Dowd KA, Normandin E, Gutiérrez-González MF, Pennington JM, De Souza MO, Henry AR, Laboune F, Wang L, Ambrozak DR, Gordon IJ, Douek DC, Ledgerwood JE, Graham BS, Castilho LR, Pierson TC, Mascola JR, DeKosky BJ. Fahad AS, et al. Among authors: castilho lr. Front Immunol. 2021 Feb 24;12:615102. doi: 10.3389/fimmu.2021.615102. eCollection 2021. Front Immunol. 2021. PMID: 33732238 Free PMC article.
Polyclonal F(ab')2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency.
Cunha LER, Stolet AA, Strauch MA, Pereira VAR, Dumard CH, Gomes AMO, Monteiro FL, Higa LM, Souza PNC, Fonseca JG, Pontes FE, Meirelles LGR, Albuquerque JWM, Sacramento CQ, Fintelman-Rodrigues N, Lima TM, Alvim RGF, Marsili FF, Caldeira MM, Zingali RB, de Oliveira GAP, Souza TML, Silva AS, Muller R, Rodrigues DDRF, Jesus da Costa L, Alves ADR, Pinto MA, Oliveira AC, Guedes HLM, Tanuri A, Castilho LR, Silva JL. Cunha LER, et al. Among authors: castilho lr. iScience. 2021 Nov 19;24(11):103315. doi: 10.1016/j.isci.2021.103315. Epub 2021 Oct 23. iScience. 2021. PMID: 34723156 Free PMC article.
Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study.
Grenfell RFQ, Almeida NBF, Filgueiras PS, Corsini CA, Gomes SVC, de Miranda DAP, Lourenço AJ, Martins-Filho OA, de Oliveira JG, Teixeira-Carvalho A, Campos GRF, Nogueira ML, Alves PA, Fernandes GR, Castilho LR, Lima TM, de Abreu DPB, Alvim RGF, Silva TBS, Jeremias WJ, Otta DA, Campi-Azevedo AC; Immunita-001 Team. Grenfell RFQ, et al. Among authors: castilho lr. Front Immunol. 2022 Jun 9;13:918896. doi: 10.3389/fimmu.2022.918896. eCollection 2022. Front Immunol. 2022. PMID: 35757764 Free PMC article. Clinical Trial.
From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemics.
Alvim RGF, Lima TM, Rodrigues DAS, Marsili FF, Bozza VBT, Higa LM, Monteiro FL, Abreu DPB, Leitão IC, Carvalho RS, Galliez RM, Castineiras TMPP, Travassos LH, Nobrega A, Tanuri A, Ferreira OC Jr, Vale AM, Castilho LR. Alvim RGF, et al. Among authors: castilho lr. Biochem Eng J. 2022 Aug;186:108537. doi: 10.1016/j.bej.2022.108537. Epub 2022 Jul 16. Biochem Eng J. 2022. PMID: 35874089 Free PMC article.
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