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Page 1
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
Moon EJ, Mello SS, Li CG, Chi JT, Thakkar K, Kirkland JG, Lagory EL, Lee IJ, Diep AN, Miao Y, Rafat M, Vilalta M, Castellini L, Krieg AJ, Graves EE, Attardi LD, Giaccia AJ. Moon EJ, et al. Among authors: castellini l. Nat Commun. 2021 Jul 14;12(1):4308. doi: 10.1038/s41467-021-24631-6. Nat Commun. 2021. PMID: 34262028 Free PMC article.
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.
Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Rankin EB, et al. Among authors: castellini l. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111. Epub 2014 Sep 3. Proc Natl Acad Sci U S A. 2014. PMID: 25187556 Free PMC article.
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells.
Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. Razorenova OV, et al. Among authors: castellini l. Mol Cell Biol. 2014 Feb;34(4):739-51. doi: 10.1128/MCB.00644-12. Epub 2013 Dec 16. Mol Cell Biol. 2014. PMID: 24344197 Free PMC article.
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Aguilera TA, et al. Among authors: castellini l. Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898. Nat Commun. 2016. PMID: 28008921 Free PMC article.
Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.
Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Wu C, et al. Among authors: castellini l. Genes Dev. 2015 Apr 15;29(8):817-31. doi: 10.1101/gad.255000.114. Epub 2015 Apr 6. Genes Dev. 2015. PMID: 25846796 Free PMC article.
BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.
Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM. Chiou SH, et al. Among authors: castellini l. Cancer Discov. 2017 Oct;7(10):1184-1199. doi: 10.1158/2159-8290.CD-17-0250. Epub 2017 Aug 8. Cancer Discov. 2017. PMID: 28790031 Free PMC article.
Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations.
Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Aguilera TA, et al. Among authors: castellini l. Clin Cancer Res. 2020 Jun 15;26(12):2972-2985. doi: 10.1158/1078-0432.CCR-19-4220. Epub 2020 Feb 25. Clin Cancer Res. 2020. PMID: 32098769 Free PMC article.
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