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Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Petrov PD, Fernández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R. Petrov PD, et al. Among authors: castell jv. Arch Toxicol. 2020 Feb;94(2):589-607. doi: 10.1007/s00204-019-02643-y. Epub 2020 Jan 1. Arch Toxicol. 2020. PMID: 31894354
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis.
García-Monzón C, Petrov PD, Rey E, Marañón P, Del Pozo-Maroto E, Guzmán C, Rodríguez de Cía J, Casado-Collado AJ, Vargas-Castrillón J, Saez A, Miquilena-Colina ME, Lo Iacono O, Castell JV, González-Rodríguez Á, Jover R. García-Monzón C, et al. Among authors: castell jv. Am J Pathol. 2018 Dec;188(12):2800-2810. doi: 10.1016/j.ajpath.2018.07.028. Epub 2018 Sep 22. Am J Pathol. 2018. PMID: 30248338 Free article.
CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model.
Benet M, Lahoz A, Guzmán C, Castell JV, Jover R. Benet M, et al. Among authors: castell jv. J Biol Chem. 2010 Sep 10;285(37):28457-71. doi: 10.1074/jbc.M110.118364. Epub 2010 Jul 9. J Biol Chem. 2010. PMID: 20622021 Free PMC article.
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.
Guzmán C, Benet M, Pisonero-Vaquero S, Moya M, García-Mediavilla MV, Martínez-Chantar ML, González-Gallego J, Castell JV, Sánchez-Campos S, Jover R. Guzmán C, et al. Among authors: castell jv. Biochim Biophys Acta. 2013 Apr;1831(4):803-18. doi: 10.1016/j.bbalip.2012.12.014. Epub 2013 Jan 12. Biochim Biophys Acta. 2013. PMID: 23318274
309 results