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Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in ex Vivo Organotypic Retinal Explant Culture Models.
Itkonen J, Annala A, Tavakoli S, Arango-Gonzalez B, Ueffing M, Toropainen E, Ruponen M, Casteleijn MG, Urtti A. Itkonen J, et al. Among authors: casteleijn mg. Pharmaceutics. 2020 Jun 30;12(7):611. doi: 10.3390/pharmaceutics12070611. Pharmaceutics. 2020. PMID: 32629980 Free PMC article.
Pharmacokinetic aspects of retinal drug delivery.
Del Amo EM, Rimpelä AK, Heikkinen E, Kari OK, Ramsay E, Lajunen T, Schmitt M, Pelkonen L, Bhattacharya M, Richardson D, Subrizi A, Turunen T, Reinisalo M, Itkonen J, Toropainen E, Casteleijn M, Kidron H, Antopolsky M, Vellonen KS, Ruponen M, Urtti A. Del Amo EM, et al. Prog Retin Eye Res. 2017 Mar;57:134-185. doi: 10.1016/j.preteyeres.2016.12.001. Epub 2016 Dec 24. Prog Retin Eye Res. 2017. PMID: 28028001 Free article. Review.
Structure-based protein engineering efforts with a monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties.
Alahuhta M, Salin M, Casteleijn MG, Kemmer C, El-Sayed I, Augustyns K, Neubauer P, Wierenga RK. Alahuhta M, et al. Among authors: casteleijn mg. Protein Eng Des Sel. 2008 Apr;21(4):257-66. doi: 10.1093/protein/gzn002. Epub 2008 Jan 31. Protein Eng Des Sel. 2008. PMID: 18239072
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