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Page 1
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.
Braun MG, Ashkenazi A, Beveridge RE, Castanedo G, Wallweber HA, Beresini MH, Clark KR, De Bruyn T, Fu L, Gibbons P, Jiang F, Kaufman S, Kan D, Kiefer JR, Leclerc JP, Lemire A, Ly C, Segal E, Sims J, Wang W, Wei W, Zhao L, Schwarz JB, Rudolph J. Braun MG, et al. Among authors: castanedo g. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.3c02425. Online ahead of print. J Med Chem. 2024. PMID: 38748820
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ, Dere E, Masureel M, Adams DJ, Volgraf M, Braun MG. Dorel R, et al. Among authors: castanedo gm. J Med Chem. 2024 Mar 28;67(6):4819-4832. doi: 10.1021/acs.jmedchem.3c02396. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470227
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Crawford JJ, Feng J, Brightbill HD, Johnson AR, Wright M, Kolesnikov A, Lee W, Castanedo GM, Do S, Blaquiere N, Staben ST, Chiang PC, Fan PW, Baumgardner M, Wong S, Godemann R, Grabbe A, Wiegel C, Sujatha-Bhaskar S, Hymowitz SG, Liau N, Hsu PL, McEwan PA, Ismaili MHA, Landry ML. Crawford JJ, et al. Among authors: castanedo gm. Bioorg Med Chem Lett. 2023 Jun 1;89:129277. doi: 10.1016/j.bmcl.2023.129277. Epub 2023 Apr 25. Bioorg Med Chem Lett. 2023. PMID: 37105490
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.
Pantua H, Skippington E, Braun MG, Noland CL, Diao J, Peng Y, Gloor SL, Yan D, Kang J, Katakam AK, Reeder J, Castanedo GM, Garland K, Komuves L, Sagolla M, Austin CD, Murray J, Xu Y, Modrusan Z, Xu M, Hanan EJ, Kapadia SB. Pantua H, et al. Among authors: castanedo gm. mBio. 2020 Sep 8;11(5):e02018-20. doi: 10.1128/mBio.02018-20. mBio. 2020. PMID: 32900806 Free PMC article.
Optimization of globomycin analogs as novel gram-negative antibiotics.
Garland K, Pantua H, Braun MG, Burdick DJ, Castanedo GM, Chen YC, Cheng YX, Cheong J, Daniels B, Deshmukh G, Fu Y, Gibbons P, Gloor SL, Hua R, Labadie S, Liu X, Pastor R, Stivala C, Xu M, Xu Y, Zheng H, Kapadia SB, Hanan EJ. Garland K, et al. Among authors: castanedo gm. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127419. doi: 10.1016/j.bmcl.2020.127419. Epub 2020 Aug 5. Bioorg Med Chem Lett. 2020. PMID: 32768648
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Parr BT, Pastor R, Sellers BD, Pei Z, Jaipuri FA, Castanedo GM, Gazzard L, Kumar S, Li X, Liu W, Mendonca R, Pavana RK, Potturi H, Shao C, Velvadapu V, Waldo JP, Wu G, Yuen PW, Zhang Z, Zhang Y, Harris SF, Oh AJ, DiPasquale A, Dement K, La H, Goon L, Gustafson A, VanderPorten EC, Mautino MR, Liu Y. Parr BT, et al. Among authors: castanedo gm. ACS Med Chem Lett. 2020 Mar 4;11(4):541-549. doi: 10.1021/acsmedchemlett.0c00004. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292562 Free PMC article.
Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).
Feng JA, Lee P, Alaoui MH, Barrett K, Castanedo G, Godemann R, McEwan P, Wang X, Wu P, Zhang Y, Harris SF, Staben ST. Feng JA, et al. Among authors: castanedo g. ACS Med Chem Lett. 2019 Jul 24;10(9):1260-1265. doi: 10.1021/acsmedchemlett.8b00658. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531194 Free PMC article.
A generalized additive model to disentangle age and diagnosis-specific cohort effects in psychological and behavioral outcomes in people living with HIV: the French cross-sectional ANRS-VESPA2 survey.
Sagaon-Teyssier L, Vilotitch A, Mora M, Maradan G, Guagliardo V, Suzan-Monti M, Dray-Spira R, Spire B; VESPA2 study group. Sagaon-Teyssier L, et al. BMC Public Health. 2019 May 17;19(1):590. doi: 10.1186/s12889-019-6905-z. BMC Public Health. 2019. PMID: 31101129 Free PMC article.
Metabolic syndrome and endocrine status in HIV-infected transwomen.
Pommier JD, Laouénan C, Michard F, Papot E, Urios P, Boutten A, Peytavin G, Ghander C, Lariven S, Castanedo G, Moho D, Landman R, Phung B, Perez E, Julia Z, Descamps D, Roland-Nicaise P, Le Gac S, Yazdanpanah Y, Guibourdenche J, Yeni P. Pommier JD, et al. Among authors: castanedo g. AIDS. 2019 Apr 1;33(5):855-865. doi: 10.1097/QAD.0000000000002152. AIDS. 2019. PMID: 30664006
40 results