Caseley EA - Search Results

1

Inflammasome activation: from molecular mechanisms to autoinflammation.

Lara-Reyna S, Caseley EA, Topping J, Rodrigues F, Jimenez Macias J, Lawler SE, McDermott MF. Lara-Reyna S, et al. Among authors: caseley ea. Clin Transl Immunology. 2022 Jul 7;11(7):e1404. doi: 10.1002/cti2.1404. eCollection 2022. Clin Transl Immunology. 2022. PMID: 35832835 Free PMC article. Review.

2

Inflammasome inhibition under physiological and pharmacological conditions.

Caseley EA, Poulter JA, Rodrigues F; Immunome Project Consortium for Autoinflammatory Disorders (ImmunAID); McDermott MF. Caseley EA, et al. Genes Immun. 2020 Aug;21(4):211-223. doi: 10.1038/s41435-020-0104-x. Epub 2020 Jul 17. Genes Immun. 2020. PMID: 32681062 Free article. Review.

3

An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7.

Caseley EA, Lara-Reyna S, Poulter JA, Topping J, Carter C, Nadat F, Spickett GP, Savic S, McDermott MF. Caseley EA, et al. J Clin Immunol. 2022 Jan;42(1):158-170. doi: 10.1007/s10875-021-01161-w. Epub 2021 Oct 21. J Clin Immunol. 2022. PMID: 34671876 Free PMC article.

4

Neurodegenerative Disease and the NLRP3 Inflammasome.

Holbrook JA, Jarosz-Griffiths HH, Caseley E, Lara-Reyna S, Poulter JA, Williams-Gray CH, Peckham D, McDermott MF. Holbrook JA, et al. Front Pharmacol. 2021 Mar 10;12:643254. doi: 10.3389/fphar.2021.643254. eCollection 2021. Front Pharmacol. 2021. PMID: 33776778 Free PMC article. Review.

5

Moving towards a systems-based classification of innate immune-mediated diseases.

Savic S, Caseley EA, McDermott MF. Savic S, et al. Among authors: caseley ea. Nat Rev Rheumatol. 2020 Apr;16(4):222-237. doi: 10.1038/s41584-020-0377-5. Epub 2020 Feb 27. Nat Rev Rheumatol. 2020. PMID: 32107482 Free article. Review.

6

Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis.

Caseley EA, Muench SP, Jiang LH. Caseley EA, et al. Proteins. 2022 Mar;90(3):619-624. doi: 10.1002/prot.26259. Epub 2021 Oct 15. Proteins. 2022. PMID: 34622987 Free article.

7

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP.

Jiang LH, Caseley EA, Muench SP, Roger S. Jiang LH, et al. Among authors: caseley ea. Purinergic Signal. 2021 Sep;17(3):331-344. doi: 10.1007/s11302-021-09790-x. Epub 2021 May 13. Purinergic Signal. 2021. PMID: 33987781 Free PMC article. Review.

8

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.

Caseley EA, Muench SP, Jiang LH. Caseley EA, et al. Purinergic Signal. 2020 Dec;16(4):485-490. doi: 10.1007/s11302-020-09730-1. Epub 2020 Oct 8. Purinergic Signal. 2020. PMID: 33029714 Free PMC article.

9

Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies.

Caseley EA, Muench SP, Jiang LH. Caseley EA, et al. Purinergic Signal. 2017 Mar;13(1):135-141. doi: 10.1007/s11302-016-9553-0. Epub 2016 Dec 26. Purinergic Signal. 2017. PMID: 28025718 Free PMC article.

10

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.

Caseley EA, Muench SP, Baldwin SA, Simmons K, Fishwick CW, Jiang LH. Caseley EA, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3164-7. doi: 10.1016/j.bmcl.2015.06.001. Epub 2015 Jun 6. Bioorg Med Chem Lett. 2015. PMID: 26099538 Free PMC article.

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