Casara P - Search Results

1

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Casara P, Davidson J, Claperon A, Le Toumelin-Braizat G, Vogler M, Bruno A, Chanrion M, Lysiak-Auvity G, Le Diguarher T, Starck JB, Chen I, Whitehead N, Graham C, Matassova N, Dokurno P, Pedder C, Wang Y, Qiu S, Girard AM, Schneider E, Gravé F, Studeny A, Guasconi G, Rocchetti F, Maïga S, Henlin JM, Colland F, Kraus-Berthier L, Le Gouill S, Dyer MJS, Hubbard R, Wood M, Amiot M, Cohen GM, Hickman JA, Morris E, Murray J, Geneste O. Casara P, et al. Oncotarget. 2018 Apr 13;9(28):20075-20088. doi: 10.18632/oncotarget.24744. eCollection 2018 Apr 13. Oncotarget. 2018. PMID: 29732004 Free PMC article.

2

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.

Murray JB, Davidson J, Chen I, Davis B, Dokurno P, Graham CJ, Harris R, Jordan A, Matassova N, Pedder C, Ray S, Roughley SD, Smith J, Walmsley C, Wang Y, Whitehead N, Williamson DS, Casara P, Le Diguarher T, Hickman J, Stark J, Kotschy A, Geneste O, Hubbard RE. Murray JB, et al. Among authors: casara p. ACS Omega. 2019 May 23;4(5):8892-8906. doi: 10.1021/acsomega.9b00611. eCollection 2019 May 31. ACS Omega. 2019. PMID: 31459977 Free PMC article.

3

Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

Gautier F, Guillemin Y, Cartron PF, Gallenne T, Cauquil N, Le Diguarher T, Casara P, Vallette FM, Manon S, Hickman JA, Geneste O, Juin P. Gautier F, et al. Among authors: casara p. Mol Cell Biol. 2011 Feb;31(4):832-44. doi: 10.1128/MCB.00161-10. Epub 2010 Dec 20. Mol Cell Biol. 2011. PMID: 21173168 Free PMC article.

4

Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.

Le Diguarher T, Ortuno JC, Shanks D, Guilbaud N, Pierré A, Raimbaud E, Fauchère JL, Hickman JA, Tucker GC, Casara PJ. Le Diguarher T, et al. Among authors: casara pj. Bioorg Med Chem Lett. 2004 Feb 9;14(3):767-71. doi: 10.1016/j.bmcl.2003.11.013. Bioorg Med Chem Lett. 2004. PMID: 14741286

5

Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors.

Le Diguarher T, Ortuno JC, Dorey G, Shanks D, Guilbaud N, Pierré A, Fauchère JL, Hickman JA, Tucker GC, Casara PJ. Le Diguarher T, et al. Bioorg Med Chem. 2003 Jul 17;11(14):3193-204. doi: 10.1016/s0968-0896(03)00218-9. Bioorg Med Chem. 2003. PMID: 12818682

6

Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist.

Burbridge MF, Venot V, Casara PJ, Perron-Sierra F, Hickman JA, Tucker GC. Burbridge MF, et al. Mol Pharmacol. 2003 Jun;63(6):1281-8. doi: 10.1124/mol.63.6.1281. Mol Pharmacol. 2003. PMID: 12761337

7

General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.

Chollet AM, Le Diguarher T, Murray L, Bertrand M, Tucker GC, Sabatini M, Pierré A, Atassi G, Bonnet J, Casara P. Chollet AM, et al. Among authors: casara p. Bioorg Med Chem Lett. 2001 Feb 12;11(3):295-9. doi: 10.1016/s0960-894x(00)00646-6. Bioorg Med Chem Lett. 2001. PMID: 11212095

8

Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.

Ferry G, Studeny A, Bossard C, Kubara PM, Zeyer D, Renaud JP, Casara P, de Nanteuil G, Wierzbicki M, Pfeiffer B, Prudhomme M, Leonce S, Pierré A, Boutin JA, Golsteyn RM. Ferry G, et al. Among authors: casara p. Life Sci. 2011 Aug 15;89(7-8):259-68. doi: 10.1016/j.lfs.2011.06.010. Epub 2011 Jun 29. Life Sci. 2011. PMID: 21736880

9

Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells.

Maubant S, Saint-Dizier D, Boutillon M, Perron-Sierra F, Casara PJ, Hickman JA, Tucker GC, Van Obberghen-Schilling E. Maubant S, et al. Among authors: casara pj. Blood. 2006 Nov 1;108(9):3035-44. doi: 10.1182/blood-2006-05-023580. Epub 2006 Jul 11. Blood. 2006. PMID: 16835373 Free article.

10

Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.

Le Diguarher T, Chollet AM, Bertrand M, Hennig P, Raimbaud E, Sabatini M, Guilbaud N, Pierré A, Tucker GC, Casara P. Le Diguarher T, et al. Among authors: casara p. J Med Chem. 2003 Aug 28;46(18):3840-52. doi: 10.1021/jm0307638. J Med Chem. 2003. PMID: 12930146

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