Carvalho I - Search Results

1

Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells.

Dos Santos DF, de Pilger DRB, Vandermeulen C, Khouri R, Mantoani SP, Nunes PSG, de Andrade P, Carvalho I, Casseb J, Twizere JC, Willems L, Freitas-Junior L, Kashima S. Dos Santos DF, et al. Among authors: carvalho i. Bioorg Med Chem. 2020 Nov 15;28(22):115746. doi: 10.1016/j.bmc.2020.115746. Epub 2020 Sep 8. Bioorg Med Chem. 2020. PMID: 33007558

2

Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol.

Bernardes LS, Kato MJ, Albuquerque S, Carvalho I. Bernardes LS, et al. Among authors: carvalho i. Bioorg Med Chem. 2006 Nov 1;14(21):7075-82. doi: 10.1016/j.bmc.2006.07.006. Bioorg Med Chem. 2006. PMID: 16908164

3

Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity.

da Silva JG, Hyppolito MA, de Oliveira JA, Corrado AP, Ito IY, Carvalho I. da Silva JG, et al. Among authors: carvalho i. Bioorg Med Chem. 2007 Jun 1;15(11):3624-34. doi: 10.1016/j.bmc.2007.03.056. Epub 2007 Mar 23. Bioorg Med Chem. 2007. PMID: 17416529

4

'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.

Carvalho I, Andrade P, Campo VL, Guedes PM, Sesti-Costa R, Silva JS, Schenkman S, Dedola S, Hill L, Rejzek M, Nepogodiev SA, Field RA. Carvalho I, et al. Bioorg Med Chem. 2010 Apr 1;18(7):2412-27. doi: 10.1016/j.bmc.2010.02.053. Epub 2010 Mar 2. Bioorg Med Chem. 2010. PMID: 20335038 Free article.

5

Using computer-aided drug design and medicinal chemistry strategies in the fight against diabetes.

Semighini EP, Resende JA, de Andrade P, Morais PA, Carvalho I, Taft CA, Silva CH. Semighini EP, et al. Among authors: carvalho i. J Biomol Struct Dyn. 2011 Apr;28(5):787-96. doi: 10.1080/07391102.2011.10508606. J Biomol Struct Dyn. 2011. PMID: 21294589

6

In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity.

da Silva VB, de Andrade P, Kawano DF, Morais PA, de Almeida JR, Carvalho I, Taft CA, da Silva CH. da Silva VB, et al. Among authors: carvalho i. Future Med Chem. 2011 Jun;3(8):947-60. doi: 10.4155/fmc.11.67. Future Med Chem. 2011. PMID: 21707398 Review.

7

Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase.

Campo VL, Sesti-Costa R, Carneiro ZA, Silva JS, Schenkman S, Carvalho I. Campo VL, et al. Among authors: carvalho i. Bioorg Med Chem. 2012 Jan 1;20(1):145-56. doi: 10.1016/j.bmc.2011.11.022. Epub 2011 Nov 22. Bioorg Med Chem. 2012. PMID: 22154559 Free article.

8

α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi.

Martins-Teixeira MB, Campo VL, Biondo M, Sesti-Costa R, Carneiro ZA, Silva JS, Carvalho I. Martins-Teixeira MB, et al. Among authors: carvalho i. Bioorg Med Chem. 2013 Apr 1;21(7):1978-87. doi: 10.1016/j.bmc.2013.01.027. Epub 2013 Feb 8. Bioorg Med Chem. 2013. PMID: 23415086 Free article.

9

Design, synthesis and enzymatic evaluation of 3-O-substituted aryl β-D-galactopyranosides as inhibitors of Trypanosoma cruzi trans-sialidase.

Silva BL, S Filho JD, Andrade P, Carvalho I, Alves RJ. Silva BL, et al. Among authors: carvalho i. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4529-4532. doi: 10.1016/j.bmcl.2014.07.088. Epub 2014 Aug 7. Bioorg Med Chem Lett. 2014. PMID: 25149510

10

1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi.

de Andrade P, Galo OA, Carvalho MR, Lopes CD, Carneiro ZA, Sesti-Costa R, de Melo EB, Silva JS, Carvalho I. de Andrade P, et al. Among authors: carvalho mr, carvalho i. Bioorg Med Chem. 2015 Nov 1;23(21):6815-26. doi: 10.1016/j.bmc.2015.10.008. Epub 2015 Oct 9. Bioorg Med Chem. 2015. PMID: 26476667

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