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Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.
Ganz AB, Shields K, Fomin VG, Lopez YS, Mohan S, Lovesky J, Chuang JC, Ganti A, Carrier B, Yan J, Taeswuan S, Cohen VV, Swersky CC, Stover JA, Vitiello GA, Malysheva OV, Mudrak E, Caudill MA. Ganz AB, et al. Among authors: carrier b. FASEB J. 2016 Oct;30(10):3321-3333. doi: 10.1096/fj.201500138RR. Epub 2016 Jun 24. FASEB J. 2016. PMID: 27342765 Free PMC article. Clinical Trial.
Overall, our findings indicate that loss-of-function variants in folate-metabolizing enzymes strain cellular PC production, possibly via impaired folate-dependent phosphatidylethanolamine-N-methyltransferase (PEMT)-PC synthesis, and suggest that women with these risk genotypes ma …
Overall, our findings indicate that loss-of-function variants in folate-metabolizing enzymes strain cellular PC production, possibly via imp …
Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.
Ganz AB, Cohen VV, Swersky CC, Stover J, Vitiello GA, Lovesky J, Chuang JC, Shields K, Fomin VG, Lopez YS, Mohan S, Ganti A, Carrier B, Malysheva OV, Caudill MA. Ganz AB, et al. Among authors: carrier b. Int J Mol Sci. 2017 Jan 26;18(2):252. doi: 10.3390/ijms18020252. Int J Mol Sci. 2017. PMID: 28134761 Free PMC article.
Bruton's tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination.
Evonuk KS, Wang S, Mattie J, Cracchiolo CJ, Mager R, Ferenčić Ž, Sprague E, Carrier B, Schofield K, Martinez E, Stewart Z, Petrosino T, Johnson GA, Yusuf I, Plaisted W, Naiman Z, Delp T, Carter L, Marušić S. Evonuk KS, et al. Among authors: carrier b. Acta Neuropathol Commun. 2023 Jul 12;11(1):115. doi: 10.1186/s40478-023-01614-w. Acta Neuropathol Commun. 2023. PMID: 37438842 Free PMC article.
32 results