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Page 1
The structural basis of ZMPSTE24-dependent laminopathies.
Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. Quigley A, et al. Among authors: carpenter ep. Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513. Science. 2013. PMID: 23539603
The structural basis of fatty acid elongation by the ELOVL elongases.
Nie L, Pascoa TC, Pike ACW, Bushell SR, Quigley A, Ruda GF, Chu A, Cole V, Speedman D, Moreira T, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Love JD, Brennan PE, Carpenter EP. Nie L, et al. Among authors: carpenter ep. Nat Struct Mol Biol. 2021 Jun;28(6):512-520. doi: 10.1038/s41594-021-00605-6. Epub 2021 Jun 10. Nat Struct Mol Biol. 2021. PMID: 34117479 Free PMC article.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP. Dong YY, et al. Among authors: carpenter ep. Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512. Science. 2015. PMID: 25766236 Free PMC article.
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP. Bushell SR, et al. Among authors: carpenter ep. Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1. Nat Commun. 2019. PMID: 31477691 Free PMC article.
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP. Rödström KEJ, et al. Among authors: carpenter ep. Nature. 2020 Jun;582(7812):443-447. doi: 10.1038/s41586-020-2250-8. Epub 2020 Apr 29. Nature. 2020. PMID: 32499642
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP. Shintre CA, et al. Among authors: carpenter ep. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716676 Free PMC article.
An overview of heavy-atom derivatization of protein crystals.
Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP. Pike AC, et al. Among authors: carpenter ep. Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Epub 2016 Mar 1. Acta Crystallogr D Struct Biol. 2016. PMID: 26960118 Free PMC article. Review.
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. Schewe M, et al. Among authors: carpenter ep. Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569. Science. 2019. PMID: 30792303 Free PMC article.
52 results