Carozza JA - Search Results

1

Discovery of VH domains that allosterically inhibit ENPP1.

Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA. Solomon PE, et al. Among authors: carozza ja. Nat Chem Biol. 2024 Jan;20(1):30-41. doi: 10.1038/s41589-023-01368-5. Epub 2023 Jul 3. Nat Chem Biol. 2024. PMID: 37400538 Free PMC article.

2

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.

Carozza JA, Brown JA, Böhnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L. Carozza JA, et al. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5. doi: 10.1016/j.chembiol.2020.07.007. Epub 2020 Jul 28. Cell Chem Biol. 2020. PMID: 32726585 Free PMC article.

3

Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway.

Ritchie C, Carozza JA, Li L. Ritchie C, et al. Among authors: carozza ja. Annu Rev Biochem. 2022 Jun 21;91:599-628. doi: 10.1146/annurev-biochem-040320-101629. Epub 2022 Mar 14. Annu Rev Biochem. 2022. PMID: 35287475 Review.

4

Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples.

Mardjuki RE, Carozza JA, Li L. Mardjuki RE, et al. Among authors: carozza ja. J Biol Chem. 2020 Apr 10;295(15):4881-4892. doi: 10.1074/jbc.RA119.012170. Epub 2020 Mar 3. J Biol Chem. 2020. PMID: 32127400 Free PMC article.

5

Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity.

Carozza JA, Böhnert V, Nguyen KC, Skariah G, Shaw KE, Brown JA, Rafat M, von Eyben R, Graves EE, Glenn JS, Smith M, Li L. Carozza JA, et al. Nat Cancer. 2020 Feb;1(2):184-196. doi: 10.1038/s43018-020-0028-4. Epub 2020 Feb 24. Nat Cancer. 2020. PMID: 33768207 Free PMC article.

6

ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.

Carozza JA, Cordova AF, Brown JA, AlSaif Y, Böhnert V, Cao X, Mardjuki RE, Skariah G, Fernandez D, Li L. Carozza JA, et al. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2119189119. doi: 10.1073/pnas.2119189119. Epub 2022 May 19. Proc Natl Acad Sci U S A. 2022. PMID: 35588451 Free PMC article.

7

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L. Lahey LJ, et al. Among authors: carozza ja. Mol Cell. 2020 Nov 19;80(4):578-591.e5. doi: 10.1016/j.molcel.2020.10.021. Epub 2020 Nov 9. Mol Cell. 2020. PMID: 33171122 Free article.

8

Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter.

Mardjuki R, Wang S, Carozza JA, Abhiraman GC, Lyu X, Li L. Mardjuki R, et al. Among authors: carozza ja. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575449. doi: 10.1101/2024.01.12.575449. bioRxiv. 2024. PMID: 38260585 Free PMC article. Preprint.

9

Validation of a non-invasive prenatal test for fetal RhD, C, c, E, K and Fy^a antigens.

Alford B, Landry BP, Hou S, Bower X, Bueno AM, Chen D, Husic B, Cantonwine DE, McElrath TF, Carozza JA, Wynn J, Hoskovec J, Gray KJ. Alford B, et al. Among authors: carozza ja. Sci Rep. 2023 Aug 7;13(1):12786. doi: 10.1038/s41598-023-39283-3. Sci Rep. 2023. PMID: 37550335 Free PMC article.

10

Maternal carrier screening with single-gene NIPS provides accurate fetal risk assessments for recessive conditions.

Hoskovec J, Hardisty EE, Talati AN, Carozza JA, Wynn J, Riku S, Ten Bosch JR, Vora NL. Hoskovec J, et al. Among authors: carozza ja. Genet Med. 2023 Feb;25(2):100334. doi: 10.1016/j.gim.2022.10.014. Epub 2022 Dec 1. Genet Med. 2023. PMID: 36454238 Free article.

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