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Page 1
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.
Armani E, Amari G, Rizzi A, De Fanti R, Ghidini E, Capaldi C, Carzaniga L, Caruso P, Guala M, Peretto I, La Porta E, Bolzoni PT, Facchinetti F, Carnini C, Moretto N, Patacchini R, Bassani F, Cenacchi V, Volta R, Amadei F, Capacchi S, Delcanale M, Puccini P, Catinella S, Civelli M, Villetti G. Armani E, et al. Among authors: carnini c. J Med Chem. 2014 Feb 13;57(3):793-816. doi: 10.1021/jm401549m. Epub 2014 Jan 29. J Med Chem. 2014. PMID: 24400806
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
Carzaniga L, Amari G, Rizzi A, Capaldi C, De Fanti R, Ghidini E, Villetti G, Carnini C, Moretto N, Facchinetti F, Caruso P, Marchini G, Battipaglia L, Patacchini R, Cenacchi V, Volta R, Amadei F, Pappani A, Capacchi S, Bagnacani V, Delcanale M, Puccini P, Catinella S, Civelli M, Armani E. Carzaniga L, et al. Among authors: carnini c. J Med Chem. 2017 Dec 28;60(24):10026-10046. doi: 10.1021/acs.jmedchem.7b01044. Epub 2017 Dec 14. J Med Chem. 2017. PMID: 29200281
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Rancati F, Linney ID, Rizzi A, Delcanale M, Knight CK, Schmidt W, Pastore F, Riccardi B, Mileo V, Carnini C, Cesari N, Blackaby WP, Patacchini R, Carzaniga L. Rancati F, et al. Among authors: carnini c. Bioorg Med Chem Lett. 2021 Jun 1;41:127975. doi: 10.1016/j.bmcl.2021.127975. Epub 2021 Mar 19. Bioorg Med Chem Lett. 2021. PMID: 33753262
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Carzaniga L, Linney ID, Rizzi A, Delcanale M, Schmidt W, Knight CK, Pastore F, Miglietta D, Carnini C, Cesari N, Riccardi B, Mileo V, Venturi L, Moretti E, Blackaby WP, Patacchini R, Accetta A, Biagetti M, Bassani F, Tondelli M, Murgo A, Battipaglia L, Villetti G, Puccini P, Catinella S, Civelli M, Rancati F. Carzaniga L, et al. Among authors: carnini c. J Med Chem. 2022 Aug 11;65(15):10233-10250. doi: 10.1021/acs.jmedchem.2c00609. Epub 2022 Jul 28. J Med Chem. 2022. PMID: 35901125
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
Moretto N, Caruso P, Bosco R, Marchini G, Pastore F, Armani E, Amari G, Rizzi A, Ghidini E, De Fanti R, Capaldi C, Carzaniga L, Hirsch E, Buccellati C, Sala A, Carnini C, Patacchini R, Delcanale M, Civelli M, Villetti G, Facchinetti F. Moretto N, et al. Among authors: carnini c. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. doi: 10.1124/jpet.114.220541. Epub 2015 Jan 9. J Pharmacol Exp Ther. 2015. PMID: 25576075
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window.
Villetti G, Carnini C, Battipaglia L, Preynat L, Bolzoni PT, Bassani F, Caruso P, Bergamaschi M, Pisano AR, Puviani V, Stellari FF, Cenacchi V, Volta R, Bertacche V, Mileo V, Bagnacani V, Moretti E, Puccini P, Catinella S, Facchinetti F, Sala A, Civelli M. Villetti G, et al. Among authors: carnini c. J Pharmacol Exp Ther. 2015 Mar;352(3):568-78. doi: 10.1124/jpet.114.220558. Epub 2015 Jan 9. J Pharmacol Exp Ther. 2015. PMID: 25576073
Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation.
Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, Viscomi AR, Pisano AR, Stokesberry S, Brunmark C, Svitacheva N, McGarvey L, Patacchini R, Damholt AB, Geppetti P, Materazzi S. Nassini R, et al. Among authors: carnini c. PLoS One. 2012;7(8):e42454. doi: 10.1371/journal.pone.0042454. Epub 2012 Aug 14. PLoS One. 2012. PMID: 22905134 Free PMC article.
Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.
Fineschi S, De Cunto G, Facchinetti F, Civelli M, Imbimbo BP, Carnini C, Villetti G, Lunghi B, Stochino S, Gibbons DL, Hayday A, Lungarella G, Cavarra E. Fineschi S, et al. Among authors: carnini c. Am J Respir Cell Mol Biol. 2013 Feb;48(2):164-71. doi: 10.1165/rcmb.2012-0111OC. Epub 2012 Nov 9. Am J Respir Cell Mol Biol. 2013. PMID: 23144333
23 results