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Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS. Saldivia M, et al. Among authors: carnielli jbt. Nat Microbiol. 2020 Oct;5(10):1207-1216. doi: 10.1038/s41564-020-0745-6. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661312 Free PMC article.
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival.
Baker N, Catta-Preta CMC, Neish R, Sadlova J, Powell B, Alves-Ferreira EVC, Geoghegan V, Carnielli JBT, Newling K, Hughes C, Vojtkova B, Anand J, Mihut A, Walrad PB, Wilson LG, Pitchford JW, Volf P, Mottram JC. Baker N, et al. Among authors: carnielli jbt. Nat Commun. 2021 Feb 23;12(1):1244. doi: 10.1038/s41467-021-21360-8. Nat Commun. 2021. PMID: 33623024 Free PMC article.
Bromodomain factor 5 is an essential regulator of transcription in Leishmania.
Jones NG, Geoghegan V, Moore G, Carnielli JBT, Newling K, Calderón F, Gabarró R, Martín J, Prinjha RK, Rioja I, Wilkinson AJ, Mottram JC. Jones NG, et al. Among authors: carnielli jbt. Nat Commun. 2022 Jul 13;13(1):4071. doi: 10.1038/s41467-022-31742-1. Nat Commun. 2022. PMID: 35831302 Free PMC article.
Proteomic analysis of the soluble proteomes of miltefosine-sensitive and -resistant Leishmania infantum chagasi isolates obtained from Brazilian patients with different treatment outcomes.
Carnielli JB, de Andrade HM, Pires SF, Chapeaurouge AD, Perales J, Monti-Rocha R, Carvalho SF, Ribeiro LP, Dietze R, Figueiredo SG, Lemos EM. Carnielli JB, et al. J Proteomics. 2014 Aug 28;108:198-208. doi: 10.1016/j.jprot.2014.05.010. Epub 2014 May 27. J Proteomics. 2014. PMID: 24874972 Clinical Trial.
13 results