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Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys.
Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Ray KP, Donnelly MC, Wahlich JC, Humphreys JI, Robinson JR, Whale GA, West MR. Crowe JS, et al. Among authors: carlton tm. Drug Dev Ind Pharm. 2019 Mar;45(3):387-394. doi: 10.1080/03639045.2018.1542708. Epub 2018 Nov 25. Drug Dev Ind Pharm. 2019. PMID: 30395728
Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients.
Nurbhai S, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Ray KP, Reckless J, Mohammed H, Irving P, MacDonald TT, Vossenkämper A, West MR, Parkes GC, Crowe JS. Nurbhai S, et al. Among authors: carlton tm. Sci Rep. 2019 Oct 1;9(1):14042. doi: 10.1038/s41598-019-50545-x. Sci Rep. 2019. PMID: 31575982 Free PMC article.