Carlier PR - Search Results

1

Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.

Du DM, Carlier PR. Du DM, et al. Among authors: carlier pr. Curr Pharm Des. 2004;10(25):3141-56. doi: 10.2174/1381612043383412. Curr Pharm Des. 2004. PMID: 15544504 Review.

2

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

Carlier PR, Du DM, Han Y, Liu J, Pang YP. Carlier PR, et al. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2335-8. doi: 10.1016/s0960-894x(99)00396-0. Bioorg Med Chem Lett. 1999. PMID: 10476864

3

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.

Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF. Yu H, et al. Among authors: carlier pr. J Pharm Biomed Anal. 2008 Jan 7;46(1):75-81. doi: 10.1016/j.jpba.2007.08.027. Epub 2007 Sep 4. J Pharm Biomed Anal. 2008. PMID: 17931815

4

Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease.

Xuan Z, Gu X, Yan S, Xie Y, Zhou Y, Zhang H, Jin H, Hu S, Mak MSH, Zhou D, Keung Tsim KW, Carlier PR, Han Y, Cui W. Xuan Z, et al. Among authors: carlier pr. ACS Chem Neurosci. 2021 Jul 7;12(13):2462-2477. doi: 10.1021/acschemneuro.1c00182. Epub 2021 Jun 22. ACS Chem Neurosci. 2021. PMID: 34156230

5

Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.

Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP. Carlier PR, et al. J Med Chem. 1999 Oct 7;42(20):4225-31. doi: 10.1021/jm990224w. J Med Chem. 1999. PMID: 10514292

6

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Wong DM, et al. Among authors: carlier pr. J Am Chem Soc. 2003 Jan 15;125(2):363-73. doi: 10.1021/ja021111w. J Am Chem Soc. 2003. PMID: 12517147

7

Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget.

Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y. Mak S, et al. Among authors: carlier pr. J Neurochem. 2021 Sep;158(6):1381-1393. doi: 10.1111/jnc.15379. Epub 2021 Jul 5. J Neurochem. 2021. PMID: 33930191 Free PMC article. Review.

8

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR. Han YF, et al. Among authors: carlier pr. Bioorg Med Chem. 1999 Nov;7(11):2569-75. doi: 10.1016/s0968-0896(99)00178-9. Bioorg Med Chem. 1999. PMID: 10632067

9

East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

Li WM, Kan KK, Carlier PR, Pang YP, Han YF. Li WM, et al. Among authors: carlier pr. Curr Alzheimer Res. 2007 Sep;4(4):386-96. doi: 10.2174/156720507781788918. Curr Alzheimer Res. 2007. PMID: 17908041 Review.

10

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Hartsel JA, et al. Among authors: carlier pr. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22738634 Free PMC article.

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