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New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia.
Zanardi A, Nardini I, Raia S, Conti A, Ferrini B, D'Adamo P, Gilberti E, DePalma G, Belloli S, Monterisi C, Coliva A, Rainone P, Moresco RM, Mori F, Zurlo G, Scali C, Natali L, Pancanti A, Giovacchini P, Magherini G, Tovani G, Salvini L, Cicaloni V, Tinti C, Tinti L, Lana D, Magni G, Giovannini MG, Gringeri A, Caricasole A, Alessio M. Zanardi A, et al. Among authors: caricasole a. Commun Biol. 2024 Jan 30;7(1):140. doi: 10.1038/s42003-024-05820-7. Commun Biol. 2024. PMID: 38291108 Free PMC article.
Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M. Migazzi A, et al. Among authors: caricasole a. Cell Rep. 2021 Apr 13;35(2):108980. doi: 10.1016/j.celrep.2021.108980. Cell Rep. 2021. PMID: 33852844 Free PMC article.
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice.
Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talpo F, Maniezzi C, Caccia C, Leoni V, Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, Caricasole A, Falqui A, Biella G, Cattaneo E. Birolini G, et al. Among authors: caricasole a. EMBO Mol Med. 2020 Oct 7;12(10):e12519. doi: 10.15252/emmm.202012519. Epub 2020 Sep 22. EMBO Mol Med. 2020. PMID: 32959531 Free PMC article.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, Lashuel HA. Hegde RN, et al. Among authors: caricasole a. EMBO J. 2020 Sep 1;39(17):e104671. doi: 10.15252/embj.2020104671. Epub 2020 Aug 5. EMBO J. 2020. PMID: 32757223 Free PMC article.
Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.
Cariulo C, Verani M, Martufi P, Ingenito R, Finotto M, Deguire SM, Lavery DJ, Toledo-Sherman L, Lee R, Doherty EM, Vogt TF, Dominguez C, Lashuel HA, Petricca L, Caricasole A. Cariulo C, et al. Among authors: caricasole a. Biochem Biophys Res Commun. 2020 Jan 15;521(3):549-554. doi: 10.1016/j.bbrc.2019.09.097. Epub 2019 Oct 31. Biochem Biophys Res Commun. 2020. PMID: 31677786
Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.
Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L. Cariulo C, et al. Among authors: caricasole a. Front Neurosci. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889. eCollection 2019. Front Neurosci. 2019. PMID: 31507364 Free PMC article.
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. Vezzoli E, et al. Among authors: caricasole a. J Clin Invest. 2019 May 6;129(6):2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. J Clin Invest. 2019. PMID: 31063986 Free PMC article.
75 results