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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity.
Fornelli C, Sofia Cento A, Nevi L, Mastrocola R, Ferreira Alves G, Caretti G, Collino M, Penna F. Fornelli C, et al. Among authors: caretti g. J Adv Res. 2024 Feb 15:S2090-1232(24)00051-1. doi: 10.1016/j.jare.2024.02.001. Online ahead of print. J Adv Res. 2024. PMID: 38365172 Free article.
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.
Parenti MD, Naldi M, Manoni E, Fabini E, Cederfelt D, Talibov VO, Gressani V, Guven U, Grossi V, Fasano C, Sanese P, De Marco K, Shtil AA, Kurkin AV, Altieri A, Danielson UH, Caretti G, Simone C, Varchi G, Bartolini M, Del Rio A. Parenti MD, et al. Among authors: caretti g. Eur J Med Chem. 2022 Dec 5;243:114683. doi: 10.1016/j.ejmech.2022.114683. Epub 2022 Sep 8. Eur J Med Chem. 2022. PMID: 36116234
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality.
Sanese P, Fasano C, Buscemi G, Bottino C, Corbetta S, Fabini E, Silvestri V, Valentini V, Disciglio V, Forte G, Lepore Signorile M, De Marco K, Bertora S, Grossi V, Guven U, Porta N, Di Maio V, Manoni E, Giannelli G, Bartolini M, Del Rio A, Caretti G, Ottini L, Simone C. Sanese P, et al. Among authors: caretti g. iScience. 2020 Oct 7;23(10):101604. doi: 10.1016/j.isci.2020.101604. eCollection 2020 Oct 23. iScience. 2020. PMID: 33205017 Free PMC article.
DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma.
Nevi L, Di Matteo S, Carpino G, Zizzari IG, Samira S, Ambrosino V, Costantini D, Overi D, Giancotti A, Monti M, Bosco D, De Peppo V, Oddi A, De Rose AM, Melandro F, Bragazzi MC, Faccioli J, Massironi S, Grazi GL, Panici PB, Berloco PB, Giuliante F, Cardinale V, Invernizzi P, Caretti G, Gaudio E, Alvaro D. Nevi L, et al. Among authors: caretti g. Hepatology. 2021 Jan;73(1):144-159. doi: 10.1002/hep.31571. Hepatology. 2021. PMID: 32978808 Free PMC article.
52 results