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The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.
Cristóvão JS, Morris VK, Cardoso I, Leal SS, Martínez J, Botelho HM, Göbl C, David R, Kierdorf K, Alemi M, Madl T, Fritz G, Reif B, Gomes CM. Cristóvão JS, et al. Among authors: cardoso i. Sci Adv. 2018 Jun 29;4(6):eaaq1702. doi: 10.1126/sciadv.aaq1702. eCollection 2018 Jun. Sci Adv. 2018. PMID: 29963623 Free PMC article.
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding.
Moreira GG, Cantrelle FX, Quezada A, Carvalho FS, Cristóvão JS, Sengupta U, Puangmalai N, Carapeto AP, Rodrigues MS, Cardoso I, Fritz G, Herrera F, Kayed R, Landrieu I, Gomes CM. Moreira GG, et al. Among authors: cardoso i. Nat Commun. 2021 Nov 1;12(1):6292. doi: 10.1038/s41467-021-26584-2. Nat Commun. 2021. PMID: 34725360 Free PMC article.
238 results