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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18.
Cell. 2021.
PMID: 33606976
Free PMC article.
Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
Fred SM, Laukkanen L, Brunello CA, Vesa L, Göös H, Cardon I, Moliner R, Maritzen T, Varjosalo M, Casarotto PC, Castrén E.
Fred SM, et al. Among authors: cardon i.
J Biol Chem. 2019 Nov 29;294(48):18150-18161. doi: 10.1074/jbc.RA119.008837. Epub 2019 Oct 20.
J Biol Chem. 2019.
PMID: 31631060
Free PMC article.
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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties.
Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel CH.
Triebelhorn J, et al. Among authors: cardon i.
Mol Psychiatry. 2022 Jun 22. doi: 10.1038/s41380-022-01660-1. Online ahead of print.
Mol Psychiatry. 2022.
PMID: 35732695
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Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression.
Cardon I, Grobecker S, Jenne F, Jahner T, Rupprecht R, Milenkovic VM, Wetzel CH.
Cardon I, et al.
Mol Psychiatry. 2024 Mar 26. doi: 10.1038/s41380-024-02538-0. Online ahead of print.
Mol Psychiatry. 2024.
PMID: 38532010
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Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease.
Cardon I, Grobecker S, Kücükoktay S, Bader S, Jahner T, Nothdurfter C, Koschitzki K, Berneburg M, Weber BHF, Stöhr H, Höring M, Liebisch G, Braun F, Rothammer-Hampl T, Riemenschneider MJ, Rupprecht R, Milenkovic VM, Wetzel CH.
Cardon I, et al.
Int J Mol Sci. 2024 Jan 12;25(2):963. doi: 10.3390/ijms25020963.
Int J Mol Sci. 2024.
PMID: 38256041
Free PMC article.
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