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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
J Biol Chem. 2019 Nov 29;294(48):18150-18161. doi: 10.1074/jbc.RA119.008837. Epub 2019 Oct 20.
J Biol Chem. 2019.
PMID: 31631060
Free PMC article.
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E.
Casarotto PC, et al. Among authors: cardon i.
Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18.
Cell. 2021.
PMID: 33606976
Free PMC article.
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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties.
Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel CH.
Triebelhorn J, et al. Among authors: cardon i.
Mol Psychiatry. 2022 Jun 22. doi: 10.1038/s41380-022-01660-1. Online ahead of print.
Mol Psychiatry. 2022.
PMID: 35732695
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Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression.
Cardon I, Grobecker S, Jenne F, Jahner T, Rupprecht R, Milenkovic VM, Wetzel CH.
Cardon I, et al.
Mol Psychiatry. 2024 Mar 26. doi: 10.1038/s41380-024-02538-0. Online ahead of print.
Mol Psychiatry. 2024.
PMID: 38532010
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Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease.
Cardon I, Grobecker S, Kücükoktay S, Bader S, Jahner T, Nothdurfter C, Koschitzki K, Berneburg M, Weber BHF, Stöhr H, Höring M, Liebisch G, Braun F, Rothammer-Hampl T, Riemenschneider MJ, Rupprecht R, Milenkovic VM, Wetzel CH.
Cardon I, et al.
Int J Mol Sci. 2024 Jan 12;25(2):963. doi: 10.3390/ijms25020963.
Int J Mol Sci. 2024.
PMID: 38256041
Free PMC article.
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