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Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D. Franceschi C, et al. Among authors: cardelli m. Mech Ageing Dev. 2005 Feb;126(2):351-61. doi: 10.1016/j.mad.2004.08.028. Mech Ageing Dev. 2005. PMID: 15621218 Review.
P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia.
Bonafè M, Olivieri F, Mari D, Baggio G, Mattace R, Berardelli M, Sansoni P, De Benedictis G, De Luca M, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Ferrucci L, Amadio L, Lisa R, Tucci MG, Troiano L, Pini G, Gueresi P, Morellini M, Sorbi S, Passeri G, Barbi C, Valensin S, Monti D, Deiana L, Pes GM, Carru C, Franceschi C. Bonafè M, et al. Among authors: cardelli m. Am J Hum Genet. 1999 Dec;65(6):1782-5. doi: 10.1086/302664. Am J Hum Genet. 1999. PMID: 10577935 Free PMC article. No abstract available.
Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE).
Franceschi C, Motta L, Valensin S, Rapisarda R, Franzone A, Berardelli M, Motta M, Monti D, Bonafè M, Ferrucci L, Deiana L, Pes GM, Carru C, Desole MS, Barbi C, Sartoni G, Gemelli C, Lescai F, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Gueresi P, Cossarizza A, Troiano L, Pini G, Sansoni P, Passeri G, Lisa R, Spazzafumo L, Amadio L, Giunta S, Stecconi R, Morresi R, Viticchi C, Mattace R, De Benedictis G, Baggio G. Franceschi C, et al. Among authors: cardelli m. Aging (Milano). 2000 Apr;12(2):77-84. doi: 10.1007/BF03339894. Aging (Milano). 2000. PMID: 10902049 Review.
A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.
Bonafè M, Olivieri F, Cavallone L, Giovagnetti S, Mayegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. Bonafè M, et al. Among authors: cardelli m. Eur J Immunol. 2001 Aug;31(8):2357-61. doi: 10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x. Eur J Immunol. 2001. PMID: 11500818 Free article.
The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.
Olivieri F, Bonafè M, Cavallone L, Giovagnetti S, Marchegiani F, Cardelli M, Mugianesi E, Giampieri C, Moresi R, Stecconi R, Lisa R, Franceschi C. Olivieri F, et al. Among authors: cardelli m. Exp Gerontol. 2002 Jan-Mar;37(2-3):309-14. doi: 10.1016/s0531-5565(01)00197-8. Exp Gerontol. 2002. PMID: 11772517
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C. Bonafè M, et al. Among authors: cardelli m. Eur J Hum Genet. 2002 May;10(5):292-6. doi: 10.1038/sj.ejhg.5200806. Eur J Hum Genet. 2002. PMID: 12082503
The role of IL-1 gene cluster in longevity: a study in Italian population.
Cavallone L, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Giovagnetti S, Di Stasio G, Giampieri C, Mugianesi E, Stecconi R, Sciacca F, Grimaldi LM, De Benedictis G, Lio D, Caruso C, Franceschi C. Cavallone L, et al. Among authors: cardelli m. Mech Ageing Dev. 2003 Apr;124(4):533-8. doi: 10.1016/s0047-6374(03)00033-2. Mech Ageing Dev. 2003. PMID: 12714264
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C. Olivieri F, et al. Among authors: cardelli m. Mech Ageing Dev. 2003 Apr;124(4):549-53. doi: 10.1016/s0047-6374(03)00035-6. Mech Ageing Dev. 2003. PMID: 12714266
90 results