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Preparation of a Key Intermediate En Route to the Anti-HIV Drug Lenacapavir.
J Org Chem. 2024 Mar 15;89(6):3995-4000. doi: 10.1021/acs.joc.3c02855. Epub 2024 Mar 6.
J Org Chem. 2024.
PMID: 38447077
Free PMC article.
A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533.
Kavthe RD, Iyer KS, Caravez JC, Lipshutz BH.
Kavthe RD, et al. Among authors: caravez jc.
Chem Sci. 2023 May 26;14(23):6399-6407. doi: 10.1039/d3sc01699d. eCollection 2023 Jun 14.
Chem Sci. 2023.
PMID: 37325157
Free PMC article.
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A 1-Pot Synthesis of the SARS-CoV-2 Mpro Inhibitor Nirmatrelvir, the Key Ingredient in Paxlovid.
Caravez JC, Iyer KS, Kavthe RD, Kincaid JRA, Lipshutz BH.
Caravez JC, et al.
Org Lett. 2022 Dec 16;24(49):9049-9053. doi: 10.1021/acs.orglett.2c03683. Epub 2022 Dec 7.
Org Lett. 2022.
PMID: 36475781
Free PMC article.
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A sustainable synthesis of the SARS-CoV-2 Mpro inhibitor nirmatrelvir, the active ingredient in Paxlovid.
Kincaid JRA, Caravez JC, Iyer KS, Kavthe RD, Fleck N, Aue DH, Lipshutz BH.
Kincaid JRA, et al. Among authors: caravez jc.
Commun Chem. 2022;5(1):156. doi: 10.1038/s42004-022-00758-5. Epub 2022 Nov 21.
Commun Chem. 2022.
PMID: 36465589
Free PMC article.
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Environmentally Responsible and Cost-Effective Synthesis of the Antimalarial Drug Pyronaridine.
Kincaid JRA, Kavthe RD, Caravez JC, Takale BS, Thakore RR, Lipshutz BH.
Kincaid JRA, et al. Among authors: caravez jc.
Org Lett. 2022 May 13;24(18):3342-3346. doi: 10.1021/acs.orglett.2c00944. Epub 2022 May 3.
Org Lett. 2022.
PMID: 35504038
Free PMC article.
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