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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, Brandimarto J, Brown MR, Buckbinder L, Carey DJ, Chasman DI, Chen X, Chen X, Chung J, Chutkow W, Cook JP, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Dunn ME, Engström G, Esko T, Felix SB, Finan C, Ford I, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gutmann R, Haggerty CM, van der Harst P, Hyde CL, Ingelsson E, Jukema JW, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Margulies KB, März W, Melander O, Mordi IR, Morgan T, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Niessner A, Niiranen T, O'Donoghue ML, Owens AT, Palmer CNA, Parry HM, Perola M, Portilla-Fernandez E, Psaty BM; Regeneron Genetics Center; Rice KM, Ridker PM, Romaine SPR, Rotter JI, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stender S, Stott DJ, Svensson P, Tammesoo ML, Taylor KD, Teder-Laving M, Teumer A,… See abstract for full author list ➔ Shah S, et al. Among authors: cappola tp. Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5. Nat Commun. 2020. PMID: 31919418 Free PMC article.
Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure.
Fermin DR, Barac A, Lee S, Polster SP, Hannenhalli S, Bergemann TL, Grindle S, Dyke DB, Pagani F, Miller LW, Tan S, Dos Remedios C, Cappola TP, Margulies KB, Hall JL. Fermin DR, et al. Among authors: cappola tp. Circ Cardiovasc Genet. 2008 Dec;1(2):117-25. doi: 10.1161/CIRCGENETICS.108.802652. Epub 2008 Dec 9. Circ Cardiovasc Genet. 2008. PMID: 20031553 Free PMC article.
Reciprocal regulation of metabolic and signaling pathways.
Barth AS, Kumordzie A, Colantuoni C, Margulies KB, Cappola TP, Tomaselli GF. Barth AS, et al. Among authors: cappola tp. BMC Genomics. 2010 Mar 24;11:197. doi: 10.1186/1471-2164-11-197. BMC Genomics. 2010. PMID: 20334672 Free PMC article.
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.
Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Haldar SM, et al. Among authors: cappola tp. Sci Transl Med. 2010 Apr 7;2(26):26ra26. doi: 10.1126/scitranslmed.3000502. Sci Transl Med. 2010. PMID: 20375365 Free PMC article.
Gene coexpression network topology of cardiac development, hypertrophy, and failure.
Dewey FE, Perez MV, Wheeler MT, Watt C, Spin J, Langfelder P, Horvath S, Hannenhalli S, Cappola TP, Ashley EA. Dewey FE, et al. Among authors: cappola tp. Circ Cardiovasc Genet. 2011 Feb;4(1):26-35. doi: 10.1161/CIRCGENETICS.110.941757. Epub 2010 Dec 2. Circ Cardiovasc Genet. 2011. PMID: 21127201 Free PMC article.
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, Nitschke PL, Patel RS; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Martinelli N, Girelli D, Quyyumi AA, Anderson JL, Erdmann J, Hall AS, Schunkert H, Quertermous T, Blankenberg S, Hazen SL, Roberts R, Kathiresan S, Samani NJ, Epstein SE, Rader DJ. Reilly MP, et al. Lancet. 2011 Jan 29;377(9763):383-92. doi: 10.1016/S0140-6736(10)61996-4. Epub 2011 Jan 14. Lancet. 2011. PMID: 21239051 Free PMC article.
Homeodomain only protein x is down-regulated in human heart failure.
Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Trivedi CM, et al. Among authors: cappola tp. J Mol Cell Cardiol. 2011 Jun;50(6):1056-8. doi: 10.1016/j.yjmcc.2011.02.015. Epub 2011 Mar 5. J Mol Cell Cardiol. 2011. PMID: 21382376 Free PMC article.
Functional genomics applied to cardiovascular medicine.
Cappola TP, Margulies KB. Cappola TP, et al. Circulation. 2011 Jul 5;124(1):87-94. doi: 10.1161/CIRCULATIONAHA.111.027300. Circulation. 2011. PMID: 21730321 Free PMC article. Review. No abstract available.
163 results