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Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome.
Gao AY, Diaz Espinosa AM, Gianì F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak AJ. Gao AY, et al. Among authors: caporarello n. Am J Physiol Lung Cell Mol Physiol. 2022 Dec 1;323(6):L685-L697. doi: 10.1152/ajplung.00023.2022. Epub 2022 Oct 12. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 36223640 Free PMC article.
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis.
Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Haak AJ, et al. Among authors: caporarello n. Sci Transl Med. 2019 Oct 30;11(516):eaau6296. doi: 10.1126/scitranslmed.aau6296. Sci Transl Med. 2019. PMID: 31666402 Free PMC article.
TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation.
Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligresti G, Tschumperlin DJ. Aravamudhan A, et al. Among authors: caporarello n. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L852-L863. doi: 10.1152/ajplung.00324.2019. Epub 2020 Mar 11. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32159970 Free PMC article.
Vascular dysfunction in aged mice contributes to persistent lung fibrosis.
Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G. Caporarello N, et al. Aging Cell. 2020 Aug;19(8):e13196. doi: 10.1111/acel.13196. Epub 2020 Jul 21. Aging Cell. 2020. PMID: 32691484 Free PMC article.
Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators.
Tan Q, Link PA, Meridew JA, Pham TX, Caporarello N, Ligresti G, Tschumperlin DJ. Tan Q, et al. Among authors: caporarello n. Am J Respir Cell Mol Biol. 2021 Apr;64(4):453-464. doi: 10.1165/rcmb.2020-0396OC. Am J Respir Cell Mol Biol. 2021. PMID: 33493091 Free PMC article.
ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.
Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. Jones DL, et al. Among authors: caporarello n. J Cell Biol. 2021 May 3;220(5):e202007152. doi: 10.1083/jcb.202007152. J Cell Biol. 2021. PMID: 33625469 Free PMC article.
40 results