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Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.
Ferlazzo GM, Gambetta AM, Amato S, Cannizzaro N, Angiolillo S, Arboit M, Diamante L, Carbognin E, Romani P, La Torre F, Galimberti E, Pflug F, Luoni M, Giannelli S, Pepe G, Capocci L, Di Pardo A, Vanzani P, Zennaro L, Broccoli V, Leeb M, Moro E, Maglione V, Martello G. Ferlazzo GM, et al. Among authors: capocci l. Nat Commun. 2023 Jul 5;14(1):3962. doi: 10.1038/s41467-023-39552-9. Nat Commun. 2023. PMID: 37407555 Free PMC article.
Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Di Pardo A, Castaldo S, Amico E, Pepe G, Marracino F, Capocci L, Giovannelli A, Madonna M, van Bergeijk J, Buttari F, van der Kam E, Maglione V. Di Pardo A, et al. Among authors: capocci l. Hum Mol Genet. 2018 Jul 15;27(14):2490-2501. doi: 10.1093/hmg/ddy153. Hum Mol Genet. 2018. PMID: 29688337
Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage.
Pepe G, Cotugno M, Marracino F, Giova S, Capocci L, Forte M, Stanzione R, Bianchi F, Marchitti S, Di Pardo A, Sciarretta S, Rubattu S, Maglione V. Pepe G, et al. Among authors: capocci l. Int J Mol Sci. 2021 Apr 6;22(7):3796. doi: 10.3390/ijms22073796. Int J Mol Sci. 2021. PMID: 33917593 Free PMC article.
Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington's disease.
Pepe G, Capocci L, Marracino F, Realini N, Lenzi P, Martinello K, Bovier TF, Bichell TJ, Scarselli P, Di Cicco C, Bowman AB, Digilio FA, Fucile S, Fornai F, Armirotti A, Parlato R, Di Pardo A, Maglione V. Pepe G, et al. Among authors: capocci l. Mol Ther. 2023 Jan 4;31(1):282-299. doi: 10.1016/j.ymthe.2022.09.004. Epub 2022 Sep 16. Mol Ther. 2023. PMID: 36116006 Free PMC article.
18 results