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Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE. Zobl W, et al. Among authors: capinha l. ALTEX. 2024;41(2):302-319. doi: 10.14573/altex.2309081. Epub 2023 Dec 4. ALTEX. 2024. PMID: 38048429 Free article.
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.
Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C. Escher SE, et al. Among authors: capinha ls. Toxicol In Vitro. 2022 Mar;79:105269. doi: 10.1016/j.tiv.2021.105269. Epub 2021 Oct 29. Toxicol In Vitro. 2022. PMID: 34757180 Free article.
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P. Capinha L, et al. Arch Toxicol. 2023 Feb;97(2):523-545. doi: 10.1007/s00204-022-03436-6. Epub 2022 Dec 28. Arch Toxicol. 2023. PMID: 36576512 Free PMC article.
"Commandeuring" Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism.
van Vugt-Lussenburg BMA, Capinha L, Reinen J, Rooseboom M, Kranendonk M, Onderwater RCA, Jennings P. van Vugt-Lussenburg BMA, et al. Among authors: capinha l. Chem Res Toxicol. 2022 Jul 18;35(7):1184-1201. doi: 10.1021/acs.chemrestox.2c00067. Epub 2022 Jun 29. Chem Res Toxicol. 2022. PMID: 35768066 Free PMC article. Review.
Corrigendum to "Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment" [Toxicol. Lett. 341 (2021) 94-106].
Capinha L, Jennings P, Commandeur JNM. Capinha L, et al. Toxicol Lett. 2021 Jun 1;343:67-68. doi: 10.1016/j.toxlet.2021.02.011. Epub 2021 Mar 6. Toxicol Lett. 2021. PMID: 33745629 No abstract available.
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