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suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury.
Nusshag C, Wei C, Hahm E, Hayek SS, Li J, Samelko B, Rupp C, Szudarek R, Speer C, Kälble F, Schaier M, Uhle F, Schmitt FC, Fiedler MO, Krautkrämer E, Cao Y, Rodriguez R, Merle U, Eugen-Olsen J, Zeier M, Weigand MA, Morath C, Brenner T, Reiser J. Nusshag C, et al. Among authors: cao y. JCI Insight. 2023 Apr 10;8(7):e165740. doi: 10.1172/jci.insight.165740. JCI Insight. 2023. PMID: 37036003 Free PMC article.
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Hahm E, et al. Among authors: cao y. Nat Med. 2017 Jan;23(1):100-106. doi: 10.1038/nm.4242. Epub 2016 Dec 12. Nat Med. 2017. PMID: 27941791 Free PMC article.
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