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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, Antonov D, Konda VR, Lindström S, Olanders G, Brandt P, Baranczewski P, Vingsbo Lundberg C, Liepinsh E, Suna E, Jones TA, Mowbray SL, Hughes D, Karlén A. Huseby DL, et al. Among authors: cao s. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5. Proc Natl Acad Sci U S A. 2024. PMID: 38579010 Free PMC article.
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).
De Rosa M, Lu L, Zamaratski E, Szałaj N, Cao S, Wadensten H, Lenhammar L, Gising J, Roos AK, Huseby DL, Larsson R, Andrén PE, Hughes D, Brandt P, Mowbray SL, Karlén A. De Rosa M, et al. Among authors: cao s. Bioorg Med Chem. 2017 Feb 1;25(3):897-911. doi: 10.1016/j.bmc.2016.12.003. Epub 2016 Dec 7. Bioorg Med Chem. 2017. PMID: 28038943 Free article.
Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues.
Loza E, Sarciaux M, Ikaunieks M, Katkevics M, Kukosha T, Trufilkina N, Ryabova V, Shubin K, Pantel L, Serri M, Huseby DL, Cao S, Yadav K, Hjort K, Hughes D, Gualtieri M, Suna E, Racine E. Loza E, et al. Among authors: cao s. Bioorg Med Chem. 2020 Jun 1;28(11):115469. doi: 10.1016/j.bmc.2020.115469. Epub 2020 Apr 3. Bioorg Med Chem. 2020. PMID: 32279921
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN. Becker K, et al. Among authors: cao s. EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2. EBioMedicine. 2021. PMID: 34740109 Free PMC article.
7,307 results