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Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors.
Giovannoni MP, Schepetkin IA, Quinn MT, Cantini N, Crocetti L, Guerrini G, Iacovone A, Paoli P, Rossi P, Bartolucci G, Menicatti M, Vergelli C. Giovannoni MP, et al. Among authors: cantini n. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1108-1124. doi: 10.1080/14756366.2018.1480615. J Enzyme Inhib Med Chem. 2018. PMID: 29969929 Free PMC article.
Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis.
Crocetti L, Vergelli C, Guerrini G, Cantini N, Kirpotina LN, Schepetkin IA, Quinn MT, Parisio C, Di Cesare Mannelli L, Ghelardini C, Giovannoni MP. Crocetti L, et al. Among authors: cantini n. Bioorg Chem. 2020 Jul;100:103880. doi: 10.1016/j.bioorg.2020.103880. Epub 2020 Apr 28. Bioorg Chem. 2020. PMID: 32388428 Free PMC article.
1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.
Cantini N, Crocetti L, Guerrini G, Vergelli C, Schepetkin IA, Pallecchi M, Bartolucci G, Quinn MT, Teodori E, Giovannoni MP. Cantini N, et al. Bioorg Med Chem Lett. 2021 Nov 15;52:128380. doi: 10.1016/j.bmcl.2021.128380. Epub 2021 Sep 24. Bioorg Med Chem Lett. 2021. PMID: 34563669 Free PMC article.
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