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The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
Costas-Insua C, Hermoso-López A, Moreno E, Montero-Fernández C, Álvaro-Blázquez A, Maroto IB, Sánchez-Ruiz A, Diez-Alarcia R, Blázquez C, Morales P, Canela EI, Casadó V, Urigüen L, Perea G, Bellocchio L, Rodríguez-Crespo I, Guzmán M. Costas-Insua C, et al. Among authors: canela ei. EMBO Mol Med. 2024 Apr;16(4):755-783. doi: 10.1038/s44321-024-00054-w. Epub 2024 Mar 21. EMBO Mol Med. 2024. PMID: 38514794 Free PMC article.
Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain.
Costas-Insua C, Moreno E, Maroto IB, Ruiz-Calvo A, Bajo-Grañeras R, Martín-Gutiérrez D, Diez-Alarcia R, Vilaró MT, Cortés R, García-Font N, Martín R, Espina M, Botta J, Ginés S, McCormick PJ, Sánchez-Prieto J, Galve-Roperh I, Mengod G, Urigüen L, Marsicano G, Bellocchio L, Canela EI, Casadó V, Rodríguez-Crespo I, Guzmán M. Costas-Insua C, et al. Among authors: canela ei. J Neurosci. 2021 Sep 22;41(38):7924-7941. doi: 10.1523/JNEUROSCI.0821-21.2021. Epub 2021 Aug 5. J Neurosci. 2021. PMID: 34353897 Free PMC article.
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43.
Maroto IB, Costas-Insua C, Berthoux C, Moreno E, Ruiz-Calvo A, Montero-Fernández C, Macías-Camero A, Martín R, García-Font N, Sánchez-Prieto J, Marsicano G, Bellocchio L, Canela EI, Casadó V, Galve-Roperh I, Núñez Á, Fernández de Sevilla D, Rodríguez-Crespo I, Castillo PE, Guzmán M. Maroto IB, et al. Among authors: canela ei. Nat Commun. 2023 Apr 21;14(1):2303. doi: 10.1038/s41467-023-38026-2. Nat Commun. 2023. PMID: 37085487 Free PMC article.
Selective inhibition of cannabinoid CB1 receptor-evoked signalling by the interacting protein GAP43.
Maroto IB, Moreno E, Costas-Insua C, Merino-Gracia J, Diez-Alarcia R, Álvaro-Blázquez A, Canales Á, Canela EI, Casadó V, Urigüen L, Rodríguez-Crespo I, Guzmán M. Maroto IB, et al. Among authors: canela ei. Neuropharmacology. 2023 Dec 1;240:109712. doi: 10.1016/j.neuropharm.2023.109712. Epub 2023 Sep 7. Neuropharmacology. 2023. PMID: 37689260 Free article.
Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.
Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E, Sánchez C. Blasco-Benito S, et al. Among authors: canela ei. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3863-3872. doi: 10.1073/pnas.1815034116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733293 Free PMC article.
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.
Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M. Moreno E, et al. Among authors: canela ei. Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19. Neuropsychopharmacology. 2018. PMID: 28102227 Free PMC article.
Cannabis Users Show Enhanced Expression of CB1-5HT2A Receptor Heteromers in Olfactory Neuroepithelium Cells.
Galindo L, Moreno E, López-Armenta F, Guinart D, Cuenca-Royo A, Izquierdo-Serra M, Xicota L, Fernandez C, Menoyo E, Fernández-Fernández JM, Benítez-King G, Canela EI, Casadó V, Pérez V, de la Torre R, Robledo P. Galindo L, et al. Among authors: canela ei. Mol Neurobiol. 2018 Aug;55(8):6347-6361. doi: 10.1007/s12035-017-0833-7. Epub 2018 Jan 2. Mol Neurobiol. 2018. PMID: 29294249
Cannabinoid receptors CB1 and CB2 form functional heteromers in brain.
Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL, Franco R, Lluis C, Canela EI, McCormick PJ. Callén L, et al. Among authors: canela ei. J Biol Chem. 2012 Jun 15;287(25):20851-65. doi: 10.1074/jbc.M111.335273. Epub 2012 Apr 24. J Biol Chem. 2012. PMID: 22532560 Free PMC article.
188 results