Canals M - Search Results

1

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.

Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: canals m. J Med Chem. 2012 Dec 13;55(23):10572-83. doi: 10.1021/jm301240t. Epub 2012 Nov 14. J Med Chem. 2012. PMID: 23150943

2

Pharmacological modulation of chemokine receptor function.

Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Scholten DJ, et al. Among authors: canals m. Br J Pharmacol. 2012 Mar;165(6):1617-1643. doi: 10.1111/j.1476-5381.2011.01551.x. Br J Pharmacol. 2012. PMID: 21699506 Free PMC article. Review.

3

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3.

Scholten DJ, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, de Esch IJ, Vischer HF, Smit MJ, Leurs R. Scholten DJ, et al. Among authors: canals m. Br J Pharmacol. 2012 Jun;166(3):898-911. doi: 10.1111/j.1476-5381.2011.01648.x. Br J Pharmacol. 2012. PMID: 21883151 Free PMC article.

4

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.

Wijtmans M, Maussang D, Sirci F, Scholten DJ, Canals M, Mujić-Delić A, Chong M, Chatalic KL, Custers H, Janssen E, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: canals m. Eur J Med Chem. 2012 May;51:184-92. doi: 10.1016/j.ejmech.2012.02.041. Epub 2012 Feb 27. Eur J Med Chem. 2012. PMID: 22424612

5

Ubiquitination of CXCR7 controls receptor trafficking.

Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R. Canals M, et al. PLoS One. 2012;7(3):e34192. doi: 10.1371/journal.pone.0034192. Epub 2012 Mar 23. PLoS One. 2012. PMID: 22457824 Free PMC article.

6

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.

Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R. Scholten DJ, et al. Among authors: canals m. Mol Pharmacol. 2014 Jan;85(1):116-26. doi: 10.1124/mol.113.088633. Epub 2013 Oct 30. Mol Pharmacol. 2014. PMID: 24174496

7

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

Schembri LS, Stoddart LA, Briddon SJ, Kellam B, Canals M, Graham B, Scammells PJ. Schembri LS, et al. Among authors: canals m. J Med Chem. 2015 Dec 24;58(24):9754-67. doi: 10.1021/acs.jmedchem.5b01664. Epub 2015 Dec 16. J Med Chem. 2015. PMID: 26632862

8

Novel Dual-Target μ-Opioid Receptor and Dopamine D₃ Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

Bonifazi A, Battiti FO, Sanchez J, Zaidi SA, Bow E, Makarova M, Cao J, Shaik AB, Sulima A, Rice KC, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: canals m. J Med Chem. 2021 Jun 10;64(11):7778-7808. doi: 10.1021/acs.jmedchem.1c00611. Epub 2021 May 20. J Med Chem. 2021. PMID: 34011153 Free PMC article.

9

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3).

Dekkers S, Comez D, Karsai N, Arimont-Segura M, Canals M, Caspar B, de Graaf C, Kilpatrick LE, Leurs R, Kellam B, Hill SJ, Briddon SJ, Stocks MJ. Dekkers S, et al. Among authors: canals m. ACS Med Chem Lett. 2023 Dec 8;15(1):143-148. doi: 10.1021/acsmedchemlett.3c00469. eCollection 2024 Jan 11. ACS Med Chem Lett. 2023. PMID: 38229752 Free PMC article.

10

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

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