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Oral ketamine reduces the experience of stress in people with chronic suicidality.
Dutton M, Can AT, Beaudequin D, Jensen E, Jones M, Gallay CC, Schwenn PE, Scherman JK, Yang C, Forsyth G, Lagopoulos J, Hermens DF. Dutton M, et al. Among authors: can at. J Affect Disord. 2022 Mar 1;300:410-417. doi: 10.1016/j.jad.2022.01.018. Epub 2022 Jan 10. J Affect Disord. 2022. PMID: 35016117
Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option.
Hermens DF, Simcock G, Dutton M, Bouças AP, Can AT, Lilley C, Lagopoulos J. Hermens DF, et al. Among authors: can at. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109921. doi: 10.1016/j.pnpbp.2020.109921. Epub 2020 Mar 10. Prog Neuropsychopharmacol Biol Psychiatry. 2020. PMID: 32169564 Review.
This may facilitate pathologically high levels of glutamate, calcium influx and subsequent excitotoxicity, which can disrupt synaptogenesis and synaptic plasticity. While studies of zinc supplementation in AN have shown some promise, the efficacy of this treatment is limit …
This may facilitate pathologically high levels of glutamate, calcium influx and subsequent excitotoxicity, which can disrupt synaptog …
Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study.
Can AT, Hermens DF, Dutton M, Gallay CC, Jensen E, Jones M, Scherman J, Beaudequin DA, Yang C, Schwenn PE, Lagopoulos J. Can AT, et al. Transl Psychiatry. 2021 Feb 4;11(1):101. doi: 10.1038/s41398-021-01230-z. Transl Psychiatry. 2021. PMID: 33542187 Free PMC article. Clinical Trial.
Participants commenced with 0.5 mg/kg of ketamine, which was titrated to a maximum 3.0 mg/kg. Follow-up assessments occurred at 4 weeks after the final dose. The primary outcome measure was the Beck Scale for Suicide Ideation (BSS) and secondary measures included scales fo …
Participants commenced with 0.5 mg/kg of ketamine, which was titrated to a maximum 3.0 mg/kg. Follow-up assessments occurred at 4 wee …
Relationships between reduction in symptoms and restoration of function and wellbeing: Outcomes of the Oral Ketamine Trial on Suicidality (OKTOS).
Beaudequin D, Can AT, Jones M, Yang C, Scherman JK, Dutton M, Schwenn P, Forsyth CGG, Jensen E, Hermens DF, Lagopoulos J. Beaudequin D, et al. Among authors: can at. Psychiatry Res. 2021 Nov;305:114212. doi: 10.1016/j.psychres.2021.114212. Epub 2021 Sep 20. Psychiatry Res. 2021. PMID: 34563973 Clinical Trial.
Animal models to improve our understanding and treatment of suicidal behavior.
Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D, Smith EG, Turecki G, Zanos P, Zarate CA Jr, Zunszain PA, Postolache TT. Gould TD, et al. Transl Psychiatry. 2017 Apr 11;7(4):e1092. doi: 10.1038/tp.2017.50. Transl Psychiatry. 2017. PMID: 28398339 Free PMC article. Review.
Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at …
Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and internation …
36 results